纳米羟基磷灰石复合材料人工骨的研究进展

发布时间：2018-04-10 13:50

本文选题：纳米羟基磷灰石 + 复合材料　；参考：《中国药房》2017年04期

【摘要】：目的:为纳米羟基磷灰石(n HAP)复合材料人工骨在骨科治疗中的应用提供参考。方法:以"纳米羟基磷灰石""人工骨""壳聚糖""聚乳酸""骨形态发生蛋白""血管内皮生长因子""n HAP""VEGF"等为关键词,分别组合查阅2005年1月-2015年12月在Pub Med及中国知网中的相关文献,对常用n HAP复合材料人工骨的种类与作用特点进行归纳和总结。结果与结论:共查阅相关文献683篇,其中有效文献36篇。常用的与n HAP复合的材料有天然高分子复合材料(如胶原、壳聚糖等)、合成高分子复合材料(如聚乳酸、聚酰胺等)、无机复合材料以及其他活性因子复合材料。n HAP复合材料人工骨具有良好的生物相容性、骨诱导性以及力学性能,在骨科临床应用中具有广阔前景。目前,亟需增强复合材料的强度、降低复合材料在体内降解速度、解决复合材料表面在体内细胞黏附等问题。
[Abstract]:Objective: to provide reference for the application of nano-hydroxyapatite (HAP) composite bone in orthopedic treatment.Methods: "nano-hydroxyapatite" "artificial bone", "chitosan", "polylactic acid", "bone morphogenetic protein", "vascular endothelial growth factor" "n HAP" "VEGF" were used as the keywords.From January 2005 to December 2015, the related literatures in Pub Med and Chinese knowledge Network were reviewed, and the types and action characteristics of the commonly used n HAP composite artificial bone were summarized and summarized.Results & conclusion: a total of 683 articles were reviewed, of which 36 were valid.Natural polymer composites (such as collagen, chitosan, etc.) and synthetic polymer composites (such as polylactic acid, poly (lactic acid), etc.) are commonly used as composite materials with n HAP.The artificial bone of polyamide, inorganic composite and other active factor composite. N HAP composite has good biocompatibility, bone induction and mechanical properties, so it has a broad prospect in clinical application in orthopedics.At present, there is an urgent need to strengthen the strength of composite materials, reduce the degradation rate of composites in vivo, and solve the problem of cell adhesion on the surface of composite materials in vivo.
【作者单位】：解放军武汉总医院药剂科;湖北中医药大学药学院;
【分类号】：R318.17;R68

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