椎间盘退化分子机制研究:现状和展望

发布时间：2018-04-11 04:29

本文选题：椎间盘 + 椎间盘退化　；参考：《中国组织工程研究》2016年02期

【摘要】：背景:椎间盘退化是古老而常见的临床疾病之一,其发病机制复杂,受到环境和基因等多种因素影响,其发病的机制仍然存在很大的争议。由于技术的局限性,以往研究对于椎间盘退化分子机制的探讨仍然不够深入,而近年来分子机制研究的有了长足的发展。目的:通过文献检索分析总结并讨论椎间盘退化的分子机制,为其有效治疗提供基础。方法:由第一作者用计算机检索相关期刊论文和Medline数据库,检索时间:2005年至2015年,检索词分别为"椎间盘、退化、分子机制、环境因素、基因、基质、降解酶、炎症因子、生化环境、治疗"和"intervertebral disc degeneration,molecular mechanism,environmental factors,Genes,matrix,degradation enzyme,inflammatory factor,biological environment,treatment",语言分别设定为中文和英文。围绕椎间盘退化的机制,从基因、细胞衰老与凋亡、降解酶与基质和炎性细胞因子等方面进行总结,探讨椎间盘退化的发生机制以及可能的有效方式。结果与结论:共检索到153篇文章,按纳入和排除标准对文献进行筛选,共纳入52篇文章。结果表明独特的结构和生化特性使得椎间盘易于发生退化。传统的观念认为环境因素(如职业、吸烟)是诱发椎间盘退化的主要因素,而目前越来越多的研究证明基因对椎间盘退化的影响才是最重要的。细胞外基质生成减少,降解酶增加,炎症因子的过表达共同造成椎间盘整体结构的破坏,加速椎间盘退化进程。椎间盘退化的有效治疗需要对其分子机制有详细的理解。尽管目前对于椎间盘退化的分子媒介有了进一步认识,椎间盘内复杂的生化环境对治疗仍是巨大的挑战。
[Abstract]:Background: disc degeneration is one of the ancient and common clinical diseases. Its pathogenesis is complex and affected by environment and gene. The pathogenesis of disc degeneration is still controversial.Due to the limitation of technology, the previous researches on the molecular mechanism of disc degeneration are still not deep enough, but in recent years, the study of molecular mechanism has made great progress.Objective: to summarize and discuss the molecular mechanism of intervertebral disc degeneration by literature retrieval.Methods: the Chinese journal full-text database and Medline database were searched by computer by the first author. The retrieval time: from 2005 to 2015, the key words were "intervertebral disc, degeneration, molecular mechanism, environmental factors, gene, matrix, degradation enzyme".Inflammatory factors, biochemical environment, treatment "and" intervertebral disc degenerationmolecular molecular mechanism "and" intervertebral disc degenerationmolecular molecular mechanism ", Chinese and English, respectively.The mechanism of disc degeneration was summarized from the aspects of gene, cell senescence and apoptosis, degradation enzyme, matrix and inflammatory cytokines, and the mechanism and possible effective way of disc degeneration were discussed.Results & conclusion: a total of 153 articles were retrieved, and 52 articles were selected according to inclusion and exclusion criteria.The results show that the intervertebral disc is prone to degeneration due to its unique structure and biochemical characteristics.The traditional view is that environmental factors (such as occupation, smoking) are the main factors that induce disc degeneration, but now more and more research has proved that gene is the most important factor to cause disc degeneration.The decrease of extracellular matrix, the increase of degradation enzyme and the overexpression of inflammatory factors lead to the destruction of the whole structure of intervertebral disc and accelerate the degenerative process of intervertebral disc.Effective treatment of disc degeneration requires a detailed understanding of its molecular mechanism.Despite the current understanding of the molecular media for disc degradation, the complex biochemical environment within the disc poses a huge challenge to treatment.
【作者单位】：解放军第二军医大学附属长征医院骨科医院脊柱外科;
【基金】：国家自然科学基金(81271351)~~
【分类号】：R681.5

【相似文献】