构建组织工程软骨支架材料:现状及未来

发布时间：2018-04-12 17:04

本文选题：软骨 + 组织支架　；参考：《中国组织工程研究》2017年10期

【摘要】：背景:众所周知,组织工程修复软骨损伤有种子细胞、支架材料、细胞因子3个要素,支架材料在软骨组织工程制备中发挥着重要作用。目的:检索近十年来国内外关于软骨组织工程支架材料的相关文献,并对其进行归纳总结,讨论支架材料发展遇到的问题及发展方向。方法:由第一作者检索2006至2016年Pub Med数据库及CNKI数据库文献,英文检索词为"cartilage tissue engineering,natural scaffold materials,synthetic scaffold materials,composite scaffolds,nanometer materials",中文检索词为"软骨组织工程,天然支架材料,人工合成支架材料,复合支架材料,纳米支架"。结果与结论:软骨组织工程支架材料来源与种类不一,天然材料、人工材料及纳米材料有各自的优点及缺点,任何单一的材料难以满足临床上对软骨的要求,将不同来源的材料按照不同比例进行复合,扬长避短,能构成力学性能良好、高孔隙率、相容性好、降解性能佳的支架材料。但目前仍存在支架材料降解过快、细胞过度生长等问题,目前相关研究大都样本量较小,缺乏长期跟踪随访,并且人体试验相对较少。
[Abstract]:Background: it is well known that there are three factors in repairing cartilage injury by tissue engineering: seed cells scaffold materials and cytokines. Scaffold materials play an important role in cartilage tissue engineering preparation.Objective: to search the literatures about cartilage tissue engineering scaffold materials in recent ten years, summarize them and discuss the problems and development trend of scaffold materials.Methods: the literature of Pub Med database and CNKI database were searched by the first author from 2006 to 2016. The English key words were "cartilage tissue engineering natural scaffold material material synthetic scaffold material material composite scaffold scaffold material materials". The Chinese key words were "cartilage tissue engineering, natural scaffold materials, artificial synthetic scaffold materials".Composite scaffold material, nano scaffold.Results & conclusion: the materials of cartilage tissue engineering scaffold are different in origin and variety. Natural materials, artificial materials and nano-materials have their own advantages and disadvantages, any single material can not meet the clinical requirements of cartilage.The materials from different sources can be combined in different proportions, which can be used as scaffolds with good mechanical properties, high porosity, good compatibility and good degradability.However, there are still some problems such as rapid degradation of scaffold materials, excessive cell growth and so on. At present, most of the related studies are relatively small, lack of long-term follow-up, and relatively few human trials.
【作者单位】：广州医科大学;深圳市第二人民医院运动医学科;深圳市组织工程重点实验室;
【基金】：深圳市科技计划项目(JCYJ2015033010240109)~~
【分类号】：R318.08;R684

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