不同体外循环时间对心脏外科手术患者血清甲状腺激素水平的影响

发布时间：2018-04-14 11:40

本文选题：体外循环 + 体外循环不同时间　；参考：《山东医药》2017年22期

【摘要】：目的观察不同体外循环(CPB)时间对心脏外科手术患者血清甲状腺激素水平的影响。方法 90例接受心脏外科手术患者,根据CPB时间长短分为A组(1.0~1.5 h)31例、B组(1.5~2.0 h)30例、C组(2.0~3.0h)29例,比较各组术前及术后24 h血清游离三碘甲腺原氨酸(FT_3)、游离甲状腺素(FT_4)、促甲状腺激素(TSH)、反三碘甲腺原氨酸(rT_3)水平。结果与同组术前相比,A、B、C组术后血清FT_3、FT_4水平低(P均0.05),rT_3水平高(P0.05)。三组术后血清FT_3、rT_3水平两两相比P均0.05。术后与A组相比,C组血清FT_4水平低(P0.05)。所有患者CPB时间与术后血清FT_3、FT_4水平呈负相关(rs分别为-0.822、-0.438,P均0.05),与术后血清rT_3水平呈正相关(rs=0.807,P0.05)。结论 CPB可导致心脏外科手术患者甲状腺激素水平异常,且CPB的时间越长,甲状腺激素水平变化越明显。
[Abstract]:Objective to observe the effect of CPB time on serum thyroid hormone levels in patients undergoing cardiac surgery.Methods according to the duration of CPB, 90 patients undergoing cardiac surgery were divided into group A (n = 31) and group B (n = 31).The serum levels of free triiodothyronine (FT _ 3), free thyroxine (FT _ 4), thyrotropin (TSH) and triiodothyronine (T _ (3)) were compared before and 24 hours after operation.Results compared with the same group before and after operation, the serum levels of FT3 and FT4 in group A were lower than those in the same group (P < 0.05) and the level of RTC _ 3 was higher than that in group A (P 0.05).The levels of serum FT _ 3 / T _ 3 in the three groups were significantly higher than those in the control group (P < 0.05).Compared with group A, serum FT_4 level in group C was lower than that in group A (P 0.05).There was a negative correlation between the time of CPB and the level of FT3 / FTCO4 in all patients after operation. The values of rs were -0.822 ~ (-0.438) (P < 0.05), respectively, and there was a positive correlation between the time of CPB and the level of serum rT_3 (0.807) (P _ (0.05)).Conclusion CPB can cause abnormal thyroid hormone level in cardiac surgery patients, and the longer the time of CPB, the more obvious the changes of thyroid hormone level.
【作者单位】：南京医科大学附属无锡市人民医院;
【分类号】：R654.2

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