注射用红花黄色素对心脏瓣膜置换术后抗凝作用的影响

发布时间：2018-04-14 17:16

本文选题：红花黄色素 + 瓣膜置换术　；参考：《辽宁中医药大学》2015年硕士论文

【摘要】：目的:本文以术前使用注射用红花黄色素作为实验组,共设立30例。同时设立30例术前给予同样剂量的生理盐水作为对照组,观察记录两组病例的入院时、手术当天及术后第一天、四天、七天的凝血指标及肝功能指标,通过对两组指标的变化进行分析研究,为注射用红花黄色素在临床应用中抗凝方面的研究提供依据。方法:本文选取2013年6月1日至2014年6月1日于沈阳军区总院心血管外科行心脏瓣膜置换(均为机械瓣膜)病人60例。根据入院顺序,运用随机数表法将病人随机分配为实验组及对照组。两组入院完善相关检查后,实验组给予注射用红花黄色素(100mg溶于250ml生理盐水1/日)静脉输液治疗,直至术前前一天。同样对照组给予同等剂量生理盐水用至术前前一天。术前两组同时应用相同剂量利尿剂、强心药等行常规抗心衰治疗。观察实验组及对照组的手术当天及术后第一天、四天、七天的肝功及凝血变化。结果:入院后完善相关检查,对两组患者的背景相似性因素进行统计分析,均P0.05,无统计学意义;实验组与对照组的手术当天、术后第一天、术后第四天及七天的肝功各项进行统计学分析,提示手术当天两组患者肝功能指标中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)P0.05,有统计学意义,余指标P0.05,无统计学意义,术后第一天、术后第四天及七天肝功两组各项指标P0.05,无统计学意义;观察两组患者同一时间的凝血功能各项指标进行对照分析,P0.05,无统计学意义,两组患者的凝血指标无差异。结论:术前应用本次试验剂量的注射用红花黄色素能够降低手术当日患者肝功中的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)指标,能够缓解肝脏功能损伤,对瓣膜置换病人术后的肝功及凝血指标无明显影响。
[Abstract]:Objective: to establish 30 cases of experimental group using safflower yellow pigment for injection before operation.At the same time, 30 cases were treated with the same dose of saline before operation as the control group. The coagulation indexes and liver function indexes were recorded on the admission day, the first day of operation and the first, fourth and seventh day after operation in the two groups.The changes of two groups of indexes were analyzed to provide the basis for the study of the anticoagulant effect of safflower yellow pigment for injection in clinical application.Methods: from June 1, 2013 to June 1, 2014, 60 patients underwent cardiac valve replacement (mechanical valve replacement) in the Department of Cardiovascular surgery, Shenyang military region General Hospital.According to the order of admission, the patients were randomly assigned to the experimental group and the control group.After the two groups were admitted to improve the relevant examination, the experimental group was given 100 mg safflower yellow pigment solution dissolved in 250ml 1 / day intravenous infusion until the day before the operation.The same control group was given the same dose of normal saline until the day before operation.Both groups were treated with the same dose of diuretics and cardioversion drugs before operation.The changes of liver function and coagulation were observed on the day of operation and the first, fourth and seventh days after operation in the experimental group and the control group.Results: there was no significant difference in the background similarity factors between the two groups (P0.05, P 0.05), the operation day of the experimental group and the control group, the first day after operation.On the 4th and 7th day after operation, the liver function indexes of the two groups were statistically analyzed. The results indicated that the liver function indexes of the two groups were alanine aminotransferase (alt) and aspartate aminotransferase (AST) P0.05, which had statistical significance, while the remaining indexes (P0.05) had no statistical significance.On the first day, on the fourth and seventh day after operation, there was no significant difference in the indexes of liver function between the two groups (P 0.05), the coagulation function indexes of the two groups were compared and analyzed at the same time (P 0.05), there was no significant difference in coagulation indexes between the two groups.Conclusion: before operation, the dosage of safflower yellow for injection can reduce the indexes of alanine aminotransferase (alt) and aspartate aminotransferase (AST) in liver function of patients on the day of operation, and can alleviate the injury of liver function.There was no significant effect on liver function and coagulation index after valvular replacement.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R654.2

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