CYP2C18基因多态性对瓣膜置换术后服用华法林剂量的影响研究

发布时间：2018-04-16 02:09

本文选题：多态性 + 单核苷酸　；参考：《重庆医学》2017年35期

【摘要】：目的探讨云贵高原汉族人群细胞色素P450(CYP)2C18、维生素K环氧化物还原酶复合体亚单位1(VKORC1)、CYP2C9的基因型分布情况及其基因多态性与华法林稳定剂量的相关性。方法以2011年1月至2014年1月在该院行瓣膜置换术后持续服用华法林抗凝治疗的云贵高原汉族患者176例为研究对象,采集静脉血检测各位点基因型,分析基因型及等位基因频率分布,以及基因多态性与华法林稳定剂量的相关性。结果各位点基因型及等位基因频率分布均符合Hardy-Winberg遗传平衡(P0.05);CYP2C18(rs7896133)、VKORC1(rs9923231)、CYP2C9(rs1057910)、CYP2C9(rs4086116)基因位点的基因多态性与华法林稳定剂量相关(P0.05)。结论云贵高原汉族患者CYP2C18(rs7896133)、VKORC1(rs9923231)、CYP2C9(rs1057910)、CYP2C9(rs4086116)基因多态性可能是华法林稳定剂量个体差异的影响因素。
[Abstract]:Objective to investigate the genotypic distribution of cytochrome P450 CYP2C18, vitamin K epoxide reductase complex subunit (VKORC1) CYP2C9 and the relationship between CYP2C9 gene polymorphism and warfarin stable dose in the Han population of Yungui Plateau.Methods from January 2011 to January 2014, 176 Han patients who received warfarin anticoagulant therapy in the hospital from January 2011 to January 2014 were selected as study subjects, and venous blood samples were collected to detect the genotypes of these patients.The frequency distribution of genotype and allele and the correlation between gene polymorphism and warfarin stable dose were analyzed.Results the genotypes and alleles frequencies of all the loci were in accordance with the polymorphism of CYP2C18rs7896133 and the polymorphism of CYP2C9 rs105791010 (CYP2C9 rs4086116) loci and the stable dose of warfarin (P0.05). The results showed that the polymorphism of CYP2C9 rs1057910 and CYP2C9 rs4086116 was consistent with that of CYP2C18 rs7896133 and VKORC1rs9923231).Conclusion the polymorphism of CYP2C18 rs7896133VKORC1 rP2C9 rs105791010P2C9 rs10P2C9 rs4086116) gene polymorphism may be the influencing factor of the individual difference of warfarin stable dose in the Han nationality patients with Yungui plateau.
【作者单位】：昆明医科大学第一附属医院心脏大血管外科;
【基金】：云南省科技厅-昆明医科大学应用基础研究联合专项资金项目(201501UH00141)
【分类号】：R654.2

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