盐酸曲马多在术后自控镇痛与超前镇痛中的应用效果比较

发布时间：2018-04-16 12:00

本文选题：盐酸曲马多 + 超前镇痛　；参考：《中国临床药学杂志》2016年05期

【摘要】：目的对比盐酸曲马多在术后自控镇痛(PCA)与超前镇痛(PA)中的应用效果。方法选择2011年8月到2015年2月择期行全身麻醉下开腹手术患者98例,根据随机抽签原则分为PA组与PCA组,各49例。PCA组给予盐酸曲马多术后PCA,PA组给予盐酸曲马多PA。结果 2组的呼吸恢复时间、唤醒时间和拔管时间对比差异都无统计学意义(P0.05)。PA组麻醉前、拔管前与拔管后24 h的疼痛评分分别为(2.13±0.45)分、(2.22±0.51)分和(1.89±0.45)分,而PCA组分别为(2.22±0.34)分、(2.31±0.41)分和(2.00±0.52)分,组间对比差异均无统计学意义(P0.05)。2组拔管前与拔管后24 h的心率与血压都明显高于麻醉前,不过PA组拔管前与拔管后24 h的心率与血压明显低于PCA组(P0.05)。PA组与PCA组拔管后24 h的恶心呕吐发生率分别为2.0%和14.3%,PA组明显低于PCA(P0.05)。结论相对于术后PCA,曲马多在PA的应用能有效保持麻醉与镇痛效果,更好地促进血流动力学的稳定,减少恶心呕吐的发生,有很好的应用价值。
[Abstract]:Objective to compare the effect of tramadol hydrochloride in postoperative PCA-controlled analgesia and preemptive analgesia.Methods from August 2011 to February 2015, 98 patients undergoing open surgery under general anesthesia were randomly divided into PA group and PCA group. 49 cases in each group were given tramadol hydrochloride after tramadol hydrochloride.Results there was no significant difference in respiratory recovery time, arousal time and extubation time between the two groups. The pain scores before and 24 hours after extubation in the PA group were 2.13 卤0.45 and 2.22 卤0.51 and 1.89 卤0.45, respectively.In PCA group, the score was 2.22 卤0.34 and 2.31 卤0.41 and 2.00 卤0.52, respectively. The heart rate and blood pressure before and 24 hours after extubation in PCA group were significantly higher than those before anesthesia.However, the heart rate and blood pressure of PA group before and 24 hours after extubation were significantly lower than those of PCA group (P 0.05). The incidence of nausea and vomiting 24 h after extubation in PA group and PCA group were 2. 0% and 14. 3% respectively, which were significantly lower than those in PCA group (P 0. 05).Conclusion compared with postoperative PCAs, tramadol in PA can effectively maintain the effect of anesthesia and analgesia, promote the stability of hemodynamics and reduce the incidence of nausea and vomiting.
【作者单位】：浙江金华广福肿瘤医院药剂科;浙江金华广福肿瘤医院麻醉科;浙江金华广福肿瘤医院普外科;
【分类号】：R614

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