同种异体骨与自体髂骨移植治疗脊柱侧凸

发布时间：2018-04-16 22:27

本文选题：髂骨 + 骨移植　；参考：《中国组织工程研究》2017年14期

【摘要】：背景:脊柱侧凸是骨科临床常见的一种脊柱畸形,临床采用自体骨移植虽能取得较好临床疗效,但存在很多局限。目的:观察同种异体骨与自体髂骨移植治疗脊柱侧凸的临床效果。方法:选择脊柱侧凸患者92例,采用后路椎弓根钉棒系统矫形内固定选择性脊柱融合术,其中46例患者将预先准备好的同种异体骨植入受骨区(观察组),另外46例患者按照所需骨量取患者两侧髂骨,修剪后植入受骨区(对照组)。术后对两组患者临床指标,Cobb角丢失率,植骨融合情况以及不良反应发生情况进行评估。结果与结论:(1)对照组患者体温恢复正常时间、白细胞计数恢复正常时间、血沉恢复正常时间以及引流管放置时间均显著短于观察组(P0.05);(2)治疗后3,9,15个月时两组患者Cobb角丢失差异均无显著性意义(P0.05);(3)治疗后3,6,12,24个月时两组患者植骨融合率差异均无显著性意义(P0.05);(4)两组患者均未发生螺钉松动,断裂和断棒等并发症。对照组感染、取骨处疼痛发生率显著高于观察组(P0.05);(5)结果表明同种异体骨与自体髂骨移植治疗脊柱侧凸可取得一致的临床疗效。
[Abstract]:Background: scoliosis is a common deformity of spine in orthopedic department.Objective: to observe the clinical effect of allograft and autogenous iliac bone transplantation in the treatment of scoliosis.Methods: 92 patients with scoliosis were treated with posterior pedicle screw system and selective spinal fusion.Among them, 46 patients implanted preprepared allogeneic bone into the recipient bone area (observation group), the other 46 patients obtained bilateral iliac bone according to the required bone mass, then pruned and implanted the recipient bone area (control group).After operation, the rate of Cobb angle loss, bone graft fusion and adverse reaction were evaluated.Results and conclusion: in the control group, the temperature returned to normal time, the white blood cell count returned to normal time,The ESR recovery time and drainage tube placement time were significantly shorter than that in the observation group (P 0.05). There was no significant difference in the loss of Cobb angle between the two groups at 15 months after treatment. There was no significant difference between the two groups at 15 months after treatment (P 0.05). The fusion rate of bone graft in the two groups at 24 months was significantly lower than that in the control group (P 0.05) and the fusion rate of bone graft in the two groups was significantly lower than that in the control group at 24 months.There was no significant difference between the two groups.Complications such as rupture and rod breakage.The incidence of bone pain in the control group was significantly higher than that in the observation group (P 0.05). The results showed that allograft and autogenous iliac bone transplantation could achieve the same clinical effect in the treatment of scoliosis.
【作者单位】：郑州市骨科医院;
【基金】：河南省科技攻关计划项目(132102310439)~~
【分类号】：R687.3

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