不同剂量羟考酮治疗全麻恢复期导尿管相关性膀胱刺激征

发布时间：2018-04-26 20:32

本文选题：羟考酮 + 导尿管插入术　；参考：《中国新药与临床杂志》2017年02期

【摘要】：目的比较不同剂量羟考酮对全麻术后导尿管相关性膀胱刺激征(CRBD)的治疗效果。方法选择全麻下普外手术结束送达麻醉恢复室后主诉有CRBD的男性患者90例,随机分为三组,每组30例。对照组静脉注射氯化钠注射液3 mL,羟考酮1组静脉注射羟考酮0.04 mg·kg~(-1),羟考酮2组静脉注射羟考酮0.08 mg·kg~(-1)。分别于给药前(T_0)、给药后10 min(T_1)和30 min(T_2)记录患者CRBD程度分级、躁动评分、疼痛视觉模拟量表(VAS)评分、Ramsay镇静评分等,并记录不良反应发生情况。结果与对照组相比,羟考酮1组和2组T_1、T_2时的CRBD程度明显改善,躁动评分和VAS评分降低,患者满意度增高,差异均有显著意义(P0.05),而羟考酮1组和2组之间比较无显著差异(P0.05)。与对照组相比,羟考酮1组和2组T_1、T_2时Ramsay评分增高(P0.05),T_1时羟考酮2组Ramsay评分高于羟考酮1组(P0.05)。羟考酮2组恶心、呕吐发生率高于羟考酮1组(30%vs.7%,P0.05)。结论羟考酮0.04 mg·kg~(-1)能缓解全麻术后CRBD,且较安全。
[Abstract]:Objective to compare the therapeutic effects of different doses of hydroxycodone on urinary catheter associated bladder irritation syndrome (CRBDD) after general anesthesia. Methods 90 male patients with CRBD were randomly divided into three groups, 30 cases in each group. The control group was treated with sodium chloride injection (3 mL), the hydroxycodone group 1 (0.04 mg / kg) and the hydroxycodone 2 group (0.08 mg / kg). CRBD grade, restlessness score, pain visual analogue scale (VAS) score and sedative score were recorded before administration, 10 min after administration and 30 min after administration. Adverse reactions were recorded. Results compared with the control group, the degree of CRBD in group 1 and group 2 were significantly improved, the scores of restlessness and VAS were decreased, and the patients' satisfaction was increased (P 0.05), but there was no significant difference between group 1 and group 2 (P 0.05). Compared with the control group, the Ramsay score of group 1 and group 2 was significantly higher than that of group 1 (P 0.05) and group 2 (P < 0.05). The Ramsay score of group 2 was higher than that of group 1 (P 0.05). The incidence of nausea and vomiting in group 2 was higher than that in group 1 (30 vs.7). Conclusion hydroxycodone 0.04 mg 路kg ~ (-1) can relieve CRBDafter general anesthesia and is safe.
【作者单位】：中国医科大学附属第一医院麻醉科;
【分类号】：R614.2

【相似文献】