长链非编码RNA对骨肉瘤的调控作用

发布时间：2018-04-27 23:33

本文选题：长链非编码RNA + 骨肉瘤　；参考：《中国生物化学与分子生物学报》2017年05期

【摘要】：骨肉瘤是一类主要发生于长管状骨的原发性恶性骨肿瘤,其主要特征是由肿瘤细胞直接形成不成熟的骨或骨组织。患者具有严重的疼痛症状和软组织肿胀,严重的可导致病理性骨折。由于骨肉瘤侵袭性较高和转移较快,其临床治疗效果较差,且患者具有较高的癌症致死率。尽管目前在骨肉瘤发生、发展的机制研究上取得了较大进展,但关于骨肉瘤的生理、病理机制尚未完全清楚。长链非编码RNA作为非编码RNA的一种,在各类肿瘤的发生和发展中发挥关键性作用;其对骨肉瘤细胞的生长、增殖、迁移、侵袭以及骨肉瘤的发生、发展、耐药性和预后也具有重要的调控作用。因此,明确长链非编码RNA在骨肉瘤中的作用,为进一步探究骨肉瘤的发病机制和临床治疗提供潜在的生物标志物。
[Abstract]:Osteosarcoma is a kind of primary malignant bone tumor which mainly occurs in long tubular bone. The main characteristic of osteosarcoma is that immature bone or bone tissue is formed directly by tumor cells. The patient has severe pain symptoms and soft tissue swelling that can lead to pathological fractures. Because of its high invasion and rapid metastasis, osteosarcoma is less effective in clinical treatment and has a higher cancer fatality rate. Although great progress has been made in the pathogenesis and development of osteosarcoma, the pathophysiological mechanism of osteosarcoma has not been fully understood. As a kind of noncoding RNA, long chain noncoding RNA plays a key role in the occurrence and development of various kinds of tumors, and it can promote the growth, proliferation, migration, invasion and development of osteosarcoma cells. Drug resistance and prognosis also play an important regulatory role. Therefore, the role of long chain noncoding RNA in osteosarcoma is clarified, which provides a potential biomarker for further exploring the pathogenesis and clinical treatment of osteosarcoma.
【作者单位】：上海体育学院运动科学学院;上海体育学院发展规划处;
【基金】：国家自然科学基金(No.81572242) 上海市人类运动能力开发与保障重点实验室(上海体育学院)(No.11DZ2261100)项目资助~~
【分类号】：R738.1

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