颅脑手术治疗患者术中自体血液回输与异体输血对其临床疗效影响及感染研究

发布时间：2018-05-03 21:39

本文选题：颅脑手术 + 自体血液回输　；参考：《中华医院感染学杂志》2017年01期

【摘要】：目的研究分析颅脑手术治疗患者术中自体血液回输与异体输血对其临床疗效及感染的影响。方法选取2014年1月-2016年1月医院收治的行颅脑手术治疗患者120例,根据术中输血血液来源不同将患者分为自体输血组和异体输血组,各60例,观察并记录两组患者术中出血量、自体血液回输量、异体血液输注量、血液输入量;比较两组患者术前、术后1、2、4、8d血红蛋白、红细胞计数、血小板计数等相关血液指标,术前、术后1、7d检测炎性因子相关指标,术后观察两组感染情况。结果两组患者术前相关检测指标均无显著差异;自体输血组术后1、4、8d红细胞计数、血红蛋白数值均显著高于异体输血组(P0.05);两组术后1、4、8d血小板计数、凝血酶原时间、部分凝血活酶时间无显著差异;两组患者术前白介素-6、干扰素-γ检测值无显著差异;自体输血组术后1、6d白介素-6和干扰素-γ检测值显著高于异体输血组(P0.05);两组患者输血后不良反应及感染情况比较,自体输血组发生率(6.67%)显著低于异体输血组(16.67%),差异有统计学意义(P0.05)。结论颅脑手术术中行自体血液回收处理并回输后对患者的免疫功能无抑制作用,红细胞形态好,携氧能力高,对术后感染的发生具有显著的降低作用。
[Abstract]:Objective to study the effect of autologous blood transfusion and allogeneic blood transfusion on the clinical efficacy and infection in patients undergoing craniocerebral surgery. Methods 120 patients with craniocerebral surgery were selected from January 2014 to January 2016. According to the blood sources of blood transfusion during operation, the patients were divided into two groups: autotransfusion group and allogeneic transfusion group (60 cases each). The blood loss during operation was observed and recorded in the two groups. Autologous blood volume, allogeneic blood transfusion volume, blood input volume, hemoglobin, erythrocyte count and platelet count were compared between the two groups before and after operation. Postoperative infection was observed in both groups. Results there was no significant difference in preoperative correlation between the two groups, erythrocyte count and hemoglobin in autologous blood transfusion group were significantly higher than those in allogeneic blood transfusion group on the 8th day after operation, platelet count and prothrombin time at 1: 4 and 8 days after operation in the two groups were significantly higher than those in the allogeneic transfusion group. There was no significant difference in the time of partial thromboplastin between the two groups, and there was no significant difference between the two groups in the detection of interleukin-6 and interferon- 纬 before operation. The detection value of interleukin-6 and interferon-纬 in autologous blood transfusion group was significantly higher than that in allogeneic blood transfusion group on the 1st and 6th day after operation, and the incidence of adverse reaction and infection in autotransfusion group was significantly lower than that in allogeneic blood transfusion group (P 0.05), and the incidence of autotransfusion group was significantly lower than that in allogeneic transfusion group (P 0.05). Conclusion the recovery and transfusion of autologous blood during craniocerebral surgery have no inhibitory effect on the immune function of the patients, red blood cells have good morphology and high oxygen carrying capacity, and it can significantly reduce the incidence of postoperative infection.
【作者单位】：丽水市人民医院输血科;湖州师范学院医学院临床系;
【基金】：浙江省医药卫生科技计划项目(2012K-B361)
【分类号】：R651.1

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