NEDD4基因多态性rs2271289与中国汉族人瘢痕疙瘩表型的相关性研究

发布时间：2018-05-05 02:21

本文选题：瘢痕疙瘩 + 单核苷酸多态性　；参考：《安徽医科大学学报》2017年08期

【摘要】：目的探讨NEDD4基因多态性rs2271289与汉族人瘢痕疙瘩相关临床表型的相关性。方法结合课题组前期瘢痕疙瘩关联分析数据,选取309例瘢痕疙瘩患者1 080例正常对照者的NEDD4基因多态性rs2271289基因分型资料,PLINK 1.07软件对选取数据资料进行分析。结果在瘢痕疙瘩患者和正常对照者比较显示NEDD4基因多态性rs2271289基因频率存在差异有统计学意义(OR=1.62,95%CI:1.24~2.10,P=3.28E-04);通过分层分析显示严重瘢痕疙瘩患者与正常对照者等位基因频率分布差异有统计学意义(P0.05),多发患者等位基因频率分布差异有统计学意义(P0.05),但家族史阳性患者和阴性患者差异无统计学意义。结论 NEDD4基因多态性rs2271289与汉族人瘢痕疙瘩发病易感性相关,此外与瘢痕疙瘩发病严重程度相关,与家族史无关。
[Abstract]:Objective to investigate the association between NEDD4 gene polymorphism rs2271289 and keloid related phenotypes in Han nationality. Methods based on the data of keloid association analysis, the data of NEDD4 polymorphism rs2271289 genotyping in 309 keloid patients were analyzed by PLINK 1.07 software. Results there was significant difference in the frequency of polymorphic rs2271289 gene of NEDD4 gene between keloid patients and normal controls. There was significant difference in the frequency of rs2271289 gene between patients with severe keloid and normal controls, and the allelic frequency scores between patients with severe keloid and normal controls were determined by stratified analysis. The frequency distribution of alleles in multiple patients was statistically significant, but there was no significant difference between positive and negative family history patients. Conclusion Polymorphic rs2271289 of NEDD4 gene is associated with susceptibility to keloid in Han nationality and is not associated with family history.
【作者单位】：安徽医科大学附属六安市人民医院皮肤性病科;安徽医科大学附属省立医院皮肤性病科;皖南医学院第一附属医院皮肤性病科;
【基金】：安徽省自然科学基金(编号:1608085MH175)
【分类号】：R622

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