乌司他丁联合大剂量氨溴索对重度烧伤患者肺功能及氧化应激的影响

发布时间：2018-05-05 12:31

本文选题：重度烧伤 + 乌司他丁　；参考：《中国现代医学杂志》2017年15期

【摘要】：目的观察乌司他丁联合大剂量氨溴索对重度烧伤患者肺功能及氧化应激的影响。方法将106例重度、特重度烧伤患者随机分为观察组(55例)和对照组(51例)。观察组在常规治疗的基础上给予乌司他丁和大剂量氨溴索(即:210 mg/t,8 h/次,静脉输注),对照组在常规治疗的基础上给予乌司他丁和常规剂量氨溴索(即:30 mg/t,8 h/次,静脉输注)。治疗10 d,观察两组肺功能相关指标[用力肺活量(FVC)、第1秒最大呼气量(FEV1)、最高呼气峰流速(PEF)、25%时瞬时流量(PEF 25%)、动脉血氧分压(PaO_2)、二氧化碳分压(PaCO_2)、PaO_2/吸入氧浓度百分比(FiO_2)]及氧化应激指标[丙二醛(MDA)、髓过氧化物酶(MPO)、脂质过氧化物(LPO)、总氧化能力(TAO)]的变化。结果 (1)两组FVC、FEV1、PEF及PEF25%水平差异有统计学意义(P0.05),观察组与对照组相比各指标水平均比较高,肺功能更好;(2)两组PaO_2、PaCO_2及PaO_2/FiO_2水平差异有统计学意义(P0.05),观察组与对照组比较各指标水平更优,血气指标水平更好;(3)两组MDA、MPO、LPO及TAO水平差异有统计学意义(P0.05),观察组与对照组相比各指标水平更低,氧化应激水平更低。结论乌司他丁联合大剂量氨溴索治疗重度烧伤患者,能改善肺功能、抑制氧化应激反应。
[Abstract]:Objective to observe the effects of ulinastatin combined with high dose ambroxol on lung function and oxidative stress in patients with severe burn. Methods 106 patients with severe and severe burn were randomly divided into observation group (n = 55) and control group (n = 51). The observation group was given ulinastatin and high-dose ambroxol (1: 210 mg / t) for 8 h / time, while the control group was given ulinastatin and ambroxol (10% 30 mg / t) for 8 h / d, while the control group was given ulinastatin and ambroxol 8 h / time on the basis of routine therapy. On the 10th day of treatment, the pulmonary function related indexes were observed [forced vital capacity (RV), FEV1 (FEV1), peak expiratory flow rate (PEFN), transient flow rate (PEF) at 25 and PEF 25T, PaO2, PaCO2PaO2 / FiO2 / FiO2] and Changes of oxidative stress index [malondialdehyde (MDA) MDAA, myeloperoxidase (MPO), lipid peroxide (LPO), total oxidation capacity (TAO)]. Results (1) the difference of PEF and PEF25% between the two groups was statistically significant (P 0.05). The levels of each index in the observation group were higher than those in the control group. There was a significant difference in Paco _ 2 and PaO_2/FiO_2 levels between the two groups (P < 0.05). The observation group and the control group were better than the control group in the level of Paco _ 2 and Paco _ 2. The difference of MDA-MPO LPO and TAO levels between the two groups was statistically significant (P 0.05). Compared with the control group, the levels of each index and oxidative stress in the observation group were lower than those in the control group. Conclusion Ulinastatin combined with high dose ambroxol can improve lung function and inhibit oxidative stress in severe burn patients.
【作者单位】：河南省郑州市第一人民医院烧伤科;
【分类号】：R644

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