射频消融术治疗甲状腺良性结节疗效的Meta分析

发布时间：2018-05-06 02:12

本文选题：射频消融 + 甲状腺良性结节　；参考：《重庆医学》2017年10期

【摘要】：目的用Meta分析的方法评价射频消融治疗甲状腺良性结节的疗效。方法计算机检索国内外数据库PubMed、Medline、EMbase、中国知网、万方数据库、生物医学文献数据库、中国医学学术会议论文数据库中关于射频消融治疗甲状腺良性结节的相关随机对照试验(RCT)及前瞻性队列研究,按照纳入与排除标准进行文献筛选和质量评价后,利用Cochrane中心提供的RevMan 5.3软件对数据进行分析。结果共纳入10篇研究文献,其中4篇RCT文献,6篇前瞻性队列研究,共356例患者,术后失访8例,通过术前、术后结节体积改变[MD=1.52,95%CI=(1.33,1.72),P0.01],无功能性结节体积改变[MD=9.67,95%CI=(4.3,15.04),P0.01],主观视觉效果评估[MD=2.89,95%CI=(2.51,3.28),P0.01],美容效果评估[MD=2.03,95%CI=(1.88,2.18),P0.01]等超声及实验室检查结果方面治疗显著;但血清游离三碘甲腺原氨酸(FT3)[MD=0.08,95%CI=(-0.08,0.24),P=0.34],血清游离甲状腺素(FT4)[MD=0.00,95%CI=(-0.04,0.05),P=0.86]未见明显改变。结论射频消融对甲状腺良性结节的疗效明显,且对甲状腺功能未见明显影响。
[Abstract]:Objective to evaluate the efficacy of radiofrequency ablation in the treatment of benign thyroid nodules by Meta analysis. Methods We searched the online database of PubMedine Medline EMbase, China knowledge Network, Wanfang Database and Biomedical Literature Database. A randomized controlled trial (RCTT) and prospective cohort study of radiofrequency ablation for benign thyroid nodules in the database of papers of the Chinese Medical Conference were carried out after literature screening and quality evaluation according to the inclusion and exclusion criteria. The data are analyzed by RevMan 5.3 software provided by Cochrane Center. Results A total of 10 articles were included in the study, including 4 articles of RCT and 6 prospective cohort studies. The changes of nodule volume [MDT 1.52C95 CII], nonfunctional nodule volume (MD9.67-95CII 4.3C 15.04P0.01), subjective visual effect assessment (MD2.89C95CI2.513.28P0.01), beauty effect assessment [MD2.0395CIT 1.882.182.18P0.01], etc., were significant in ultrasound and laboratory examination. But the serum free triiodothyronine (FT3) [MDT 0.08J 95] [MDN 0.08J 0.24C P0. 34] and serum free thyroxine FT4] [MD0. 0095] [MD0. 0095CIX-0. 04 + 0. 05 P0. 86] there was no significant change in the level of serum free thyroxine (MD0. 0095% ~ 0. 05% P + 0. 86), but no significant change was found in the serum free triiodothyronine. Conclusion radiofrequency ablation is effective in the treatment of benign thyroid nodules and has no significant effect on thyroid function.
【作者单位】：新疆医科大学第一附属医院血管甲状腺外科;新疆生产建设兵团总医院普外科;
【分类号】：R653

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