颅内动脉瘤夹闭术后脑梗死的危险因素分析

发布时间：2018-05-08 14:45

本文选题：动脉瘤 + 术后脑梗死　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:探讨颅内动脉瘤夹闭术后发生脑梗死的相关危险因素。方法:回顾性分析2012年1月-2016年6月期间在广西医科大学第一附属医院神经外科行颅内动脉瘤夹闭术的143例颅内动脉瘤患者的临床资料,分别对143例患者的年龄、性别、吸烟史、糖尿病史、高血压病史、入院时的WFNS分级、Hunt-Hess分级、改良Fisher分级、手术时机、脑血管痉挛、术中临时阻断载瘤动脉、术中动脉瘤破裂、瘤体大小、位置等14个指标进行单因素分析,理论频数小于5者使用Fisher确切概率法,筛选出有显著性的单因素,再进行多因素Logistic回归模型分析,得出颅内动脉瘤开颅夹闭术后脑梗死的危险因素,并对结果进行讨论和分析,P0.05被认为差异有统计学意义。结果:单因素统计学分析颅内瘤夹闭术后发生脑梗死的危险因素包括患者的H-H等级评分、脑血管痉挛、术中破裂;将单因素分析差异有显著性的因素进行Logistic回归模型的多因素分析,结果显示:脑血管痉挛及术中动脉瘤破裂是颅内动脉瘤夹闭术后发生脑梗死的危险因素。结论:脑血管痉挛和术中动脉瘤破裂是颅内动脉瘤夹闭术后发生脑梗死的独立危险因素,两者均可能增加颅内动脉瘤夹闭术后脑梗死的发生风险。
[Abstract]:Objective: to investigate the risk factors of cerebral infarction after intracranial aneurysm clipping. Methods: the clinical data of 143 patients undergoing intracranial aneurysm clipping from January 2012 to June 2016 in the Neurosurgery Department of the first affiliated Hospital of Guangxi Medical University were retrospectively analyzed. History of smoking, history of diabetes, history of hypertension, WFNS grade on admission and Hunt-Hess grade, modified Fisher grade, timing of operation, cerebral vasospasm, temporary occlusion of aneurysm during operation, rupture of aneurysm during operation, tumor size, The 14 indexes such as position were analyzed by single factor analysis. Those whose theoretical frequency was less than 5 used Fisher exact probability method to screen out the significant single factor, and then carried out the multivariate Logistic regression model analysis. The risk factors of cerebral infarction after intracranial aneurysm clipping were obtained and the results were discussed and analyzed (P0.05). Results: univariate statistical analysis of the risk factors of cerebral infarction after intracranial tumor clipping included H-H grade score, cerebral vasospasm, intraoperative rupture. The multivariate analysis of univariate analysis showed that cerebral vasospasm and aneurysm rupture during operation were the risk factors of cerebral infarction after intracranial aneurysm clipping. Conclusion: cerebral vasospasm and aneurysm rupture during operation are independent risk factors of cerebral infarction after intracranial aneurysm clipping, both of which may increase the risk of cerebral infarction after intracranial aneurysm clipping.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R651.12

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