预后营养指数（PNI）与克罗恩病术后近期并发症的相关性研究

发布时间：2018-05-09 03:41

本文选题：克罗恩病 + 预后营养指数　；参考：《浙江大学》2015年硕士论文

【摘要】：目的：探讨预后营养指数(PNI)对克罗恩病患者术后近期并发症的预测作用。方法：本研究收集2012年1月至2014年12月的73例行肠段切除的克罗恩病患者的临床资料。男性46例,女性27例,平均年龄36.14岁。根据患者术前外周血白蛋白和淋巴细胞计数,采用公式10×白蛋白浓度(g/dl)+0.005×淋巴细胞计数(/mm3)计算PNI值。将患者分为两组：一组PNI40(30例),另一组PNI40(43例),比较两组间临床和实验室各项指标差异,并采用logistic回归分析并发症相关危险因素。结果：PNI40和PNI40两组间BMI(17.9±2.4vs.19.2±2.25,p0.05)差异有统计学意义。PNI40组术后总体并发症和感染性并发症例数分别是15例(50.0%)和14例(46.7%)；PNI≥40组分别是10例(23.3%)和7例(16.3%),差异有统计学意义p0.05)。术后住院天数两组间差异无统计学意义60=0.138)。单因素分析显示BMI18.5,穿透型病变,传统开放手术和PNI40与总体并发症和感染性并发症相关。而多因素分析提示只有PNI40是感染性并发症的独立预后指标(OR：3.846,95%置信区间[1.145-12.821])。结论：术前预后营养指数(PNI)是克罗恩病患者术后近期感染性并发症的有效预测指标。
[Abstract]:Objective: to investigate the prognostic effect of PNII on postoperative complications in patients with Crohn's disease. Methods: the clinical data of 73 patients with Crohn's disease were collected from January 2012 to December 2014. There were 46 males and 27 females with an average age of 36.14 years. According to the preoperative peripheral blood albumin and lymphocyte count, the PNI value was calculated by the formula of 10 脳 albumin concentration (g / dl) 0.005 脳 lymphocyte count (r / mm ~ (3)). The patients were divided into two groups: one group of PNI40(30 cases and the other group of PNI40(43 cases. The differences of clinical and laboratory indexes between the two groups were compared, and the risk factors of complications were analyzed by logistic regression analysis. Results there was a significant difference in BMI(17.9 卤2.4vs.19.2 卤2.25 2.4vs.19.2 between the two groups. The total postoperative complications and infectious complications in the PNI40 group were 15 cases (50.0%) and 14 cases (46.7%) were 10 cases (23. 3%) and 7 cases (16. 3%), respectively. The difference was statistically significant (p0 05). There was no significant difference in postoperative hospitalization days between the two groups. Univariate analysis showed that BMI 18. 5, penetrating lesions, traditional open surgery and PNI40 were associated with overall and infectious complications. Multivariate analysis showed that only PNI40 was an independent prognostic marker of infectious complications with OR: 3.846 / 95% confidence interval [1.145-12.821]. Conclusion: preoperative prognostic nutrition index (PNII) is an effective predictor of postoperative infectious complications in patients with Crohn's disease.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R656.9

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