麻醉下的脑电信号同步分析

发布时间：2018-05-09 11:02

本文选题：头皮脑电 + 皮层脑电　；参考：《燕山大学》2015年硕士论文

【摘要】：同步已经成为描述全身麻醉下脑区之间信息传递神经生理机制的重要工具。不同同步方法在反应不同麻醉状态下的脑电信号形式表现各自的性能特点。然而,丙泊酚诱导的麻醉过程中不同脑区上的同步性变化还没有完全阐述清楚。本文计算了七个受试者在丙泊酚全身麻醉过程中双通道头皮信号的同步指标值。为了评估同步指标的性能及指标之间相关性,计算了同步指标与双频谱指数和丙泊酚效应室浓度之间的预测概率、不同麻醉状态下的变异系数以及皮尔逊相关系数。结果表明,不同同步方法在评估麻醉过程中双通道头皮信号间的同步变化具有不同的表现形式。排序交叉互信息,确定性在预测双频谱指数和跟随效应室浓度的性能上优于非线性相互依存,基于核密度估计的互信息和交叉互相关。排序互信息和非线性相互依存指标值在无意识期有明显的升高,在恢复期有明显的下降,但对基于核估计的互信息,确定性和小波一致性,则趋势相反。基于相位锁的相位同步指标值在无意识期降低,但在恢复期却没有显著变化。本文还通过相位幅度耦合方法分析了三个癫痫病人在丙泊酚麻醉下64通道的皮层信号同步变化。时变相位幅度调制图和基于Kullback-Leibler距离的调制指标用来分析了清醒期和无意识期三个病人在额叶、顶叶、枕叶和颞叶皮层中低频的慢波振荡(1Hz)、δ(1-4Hz)振荡、θ(4-8Hz)振荡和高频的α(8-13Hz)振荡、β(13-30Hz)振荡、γ1(30-40Hz)振荡之间的相位幅度耦合模式和耦合强度。结果表明,丙泊酚对不同皮层区域中不同频段之间的相位幅度耦合有不同的影响。相位幅度耦合“波谷-最大”模式出现在清醒期顶叶和枕叶皮层的调控中,“波峰-最大”模式出现在无意识期的额叶、顶叶和枕叶皮层的调控中。此外,新发现的被称之为“下降沿-最大”模式的新的相位幅度耦合模式则主要出现在意识消失之后的额叶、顶叶和枕叶皮层中的调控中。
[Abstract]:Synchronization has become an important tool to describe the neurophysiological mechanism of information transmission between brain regions under general anesthesia. Different synchronization methods show their own performance characteristics in response to different anesthetic state. However, the changes of synchronism in different brain regions during propofol induced anesthesia have not been fully explained. The synchronous scalp signals of seven subjects during general anesthesia with propofol were calculated. In order to evaluate the performance of synchronization index and its correlation, the prediction probability of synchronization index, bispectral index and propofol effect chamber concentration, the coefficient of variation and Pearson correlation coefficient under different anesthetic conditions were calculated. The results showed that different synchronization methods had different forms in evaluating the synchronization changes between two channels scalp signals during anaesthesia. Ranking cross-mutual information, deterministic performance in predicting bispectral exponent and concentration of following effect chamber is superior to nonlinear interdependence, and mutual information and cross-correlation based on kernel density estimation. The values of ranking mutual information and nonlinear interdependence index increased obviously in unconscious period and decreased obviously in convalescence period, but for mutual information based on kernel estimation, deterministic and wavelet consistency showed the opposite trend. The phase synchronization index based on phase lock decreased in the unconscious period, but did not change significantly in the recovery period. The synchronous changes of 64 channel cortical signals in three epileptic patients under propofol anesthesia were also analyzed by phase amplitude coupling method. The time-varying phase amplitude modulation map and the modulation index based on Kullback-Leibler distance were used to analyze three patients in frontal lobe and parietal lobe. The phase amplitude coupling mode and coupling intensity between low frequency slow wave oscillations in occipital lobe and temporal cortex (1Hzn, 未 -1-4Hz), 胃 ~ (4-8) Hz) and high-frequency 伪 _ (8-13 ~ (13) Hz), 尾 ~ (13 ~ (13) H _ (z) and 纬 _ 130-40 Hz) oscillations in the occipital lobe and temporal cortex. The results show that propofol has different effects on the phase amplitude coupling between different frequency bands in different cortical regions. The phase amplitude coupling "trough maximum" pattern appears in the regulation of the parietal lobe and occipital cortex in the awake period, and the "peak maximum" pattern in the frontal, parietal and occipital cortex in the unconscious phase. In addition, the newly discovered phase amplitude coupling model, called the "descending edge-maximum" mode, mainly occurs in the frontal, parietal and occipital cortex after consciousness has disappeared.
【学位授予单位】：燕山大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R614;TN911.6

【共引文献】