骨疏康胶囊治疗膝骨关节炎效果及对IL-1、MMP-1、MMP-3及TIMP-1表达的影响

发布时间：2018-05-10 20:37

本文选题：膝骨关节炎 + 骨疏康　；参考：《中国老年学杂志》2017年17期

【摘要】：目的探讨膝骨性关节炎(KOA)患者采用骨疏康治疗的效果及对血清白细胞介素(IL)-1、基质金属蛋白酶(MMP)-1、MMP-3、基质金属蛋白酶抑制剂(TIMP)-1水平的影响。方法选取82例(109膝)KOA患者,采用随机数字表法分为中医组、西医组各41例,两组均给予盐酸氨基葡萄糖胶囊治疗,中医组同时加用骨疏康,治疗12 w后对比临床效果。结果治疗后,中医组血清IL-1、MMP-1、MMP-3水平低于西医组,TIMP-1水平高于西医组(P0.05),中医组关节疼痛、关节屈伸不利、关节压痛、下肢酸胀、关节皮肤发热、行走疼痛不适积分低于西医组(P0.05);治疗后,中医组愈显率高于西医组(P0.05),中医组总有效率高于西医组,但差异无统计学意义(P0.05)。结论 KOA患者采用骨疏康治疗效果较好,能显著降低患者血清IL-1、MMP-1、MMP-3、TIMP-1水平。
[Abstract]:Objective to investigate the effect of treating patients with knee osteoarthritis (KOAA) with Guxukang and its effects on the levels of serum interleukin-1 (IL-1), matrix metalloproteinase (MMP-1)-1 and matrix metalloproteinase inhibitor (TIMP)-1. Methods 82 patients with Koa of 109 knees were randomly divided into Chinese medicine group (n = 41) and western medicine group (n = 41). The two groups were treated with glucosamine hydrochloride capsule, and the Chinese medicine group were treated with Gushukang at the same time. After 12 weeks of treatment, the clinical effects were compared. Results after treatment, the level of serum IL-1MMP 1 MMP-3 in TCM group was lower than that in western medicine group (P 0.05). The joint pain, joint flexion and extension disadvantage, joint tenderness, lower extremity distention and skin fever were observed in TCM group. The discomfort score of walking pain was lower than that of western medicine group (P 0.05), the effective rate of TCM group was higher than that of western medicine group (P 0.05), the total effective rate of TCM group was higher than that of western medicine group, but the difference was not statistically significant (P 0.05). Conclusion Gushukang is effective in treating KOA patients, and it can significantly reduce the level of serum IL-1MMP 1, MMP-3 and TIMP-1.
【作者单位】：青海省第五人民医院骨科;青海省第五人民医院肿瘤内科;
【分类号】：R684.3

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