负载妥布霉素的硫酸钙治疗老年慢性骨髓炎的临床研究

发布时间：2018-05-12 13:24

本文选题：负载妥布霉素的硫酸钙 + 慢性骨髓炎　；参考：《中国临床药理学杂志》2017年11期

【摘要】：目的观察负载妥布霉素的硫酸钙(Osteoset-T)治疗老年慢性骨髓炎的临床疗效及安全性。方法将52例老年慢性骨髓炎患者随机分为对照组26例和试验组26例。2组患者均予以清创手术治疗,在此基础上,对照组予以庆大霉素骨水泥(4 mg·g~(~(-1)))填塞清创后空腔,试验组予以Osteoset-T(4%妥布霉素)填塞清创后空腔。2组患者均治疗7 d。比较2组患者的临床疗效、血清溶菌酶(LZM)、C反应蛋白(CRP)、以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为88.46%(23/26例)和65.38%(17/26例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的LZM分别为(22.45±1.78),(18.54±1.32)μg·L~(~(-1));CRP分别为(1.58±0.22),(3.86±0.43)mg·L~(~(-1)),差异均有统计学意义(均P0.05)。试验组发生局部渗液,对照组发生局部渗液和伤口愈合延迟。试验组和对照组的药物不良反应的发生率分别为3.85%和7.69%,差异无统计学意义(P0.05)。结论 Osteoset-T治疗老年慢性骨髓炎的临床疗效显著,其能显著提高患者的血清LZM水平,降低血清CRP水平,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the clinical efficacy and safety of tobramycin loaded calcium sulfate (Osteoset-T) in the treatment of senile chronic osteomyelitis. Methods 52 elderly patients with chronic osteomyelitis were randomly divided into control group (n = 26) and experimental group (n = 26). Osteoset-TX 4% tobramycin (Osteoset-TX 4% tobramycin) was given to all the patients in the experimental group for 7 days after debridement. The clinical efficacy, serum lysozyme, C-reactive protein (CRP) and adverse drug reaction (ADR) were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 88.46 / 23 / 26 and 65.38 / 17 / 26, respectively. The difference was statistically significant (P 0.05). After treatment, the LZM levels in the experimental group and the control group were 22.45 卤1.78 卤1.32 渭 g / L and 3.86 卤0.22 渭 g / L, respectively (P 0.05). Local exudation occurred in the test group and delayed wound healing in the control group. The incidence of adverse drug reactions in the test group and the control group were 3.85% and 7.69%, respectively, with no significant difference (P 0.05). Conclusion Osteoset-T is effective in the treatment of senile chronic osteomyelitis. It can significantly increase the level of serum LZM and decrease the level of serum CRP without increasing the incidence of adverse drug reactions.
【作者单位】：浙江省立同德医院骨科;
【基金】：浙江省医药卫生科技计划基金资助项目(2012RCA011)
【分类号】：R681.2

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