注射用尖吻蝮蛇血凝酶在肝切除手术中止血效果及安全性的比较

发布时间：2018-05-15 01:33

本文选题：肝切除术 + 注射用尖吻蝮蛇血凝酶　；参考：《重庆医学》2017年08期

【摘要】：目的比较注射用尖吻蝮蛇血凝酶与其他止血药物在肝切除术中的止血效果,并观察临床安全性。方法将2014年11月至2016年2月该院肝胆外科行肝切除术的122例患者按照术前纳入及排除标准分为注射用尖吻蝮蛇血凝酶(A组)、注射用矛头蝮蛇血凝酶(B组)及醋酸去氨加压素注射液组(C组),按照临床研究方案给药后对3组患者疗效性指标(切口创面止血时间、切口创面出血量、术后24h引流量)和手术前、后安全性指标(血常规、凝血功能、肝肾功能)进行比较。结果 3组患者的切口创面止血时间、切口创面出血量、术后24h引流量差异无统计学意义(P0.05);各组患者血常规、凝血功能、肝肾功能指标给药前和给药后第3天组间及组内比较,差异无统计学意义(P0.05);出院时心电图、双下肢B超检查均未见异常;本次临床研究中各组病例无不良事件发生。结论注射用尖吻蝮蛇血凝酶在肝切除术中的止血效果与其他止血药相似,对手术后血常规、凝血功能、肝肾功能指标无影响,具有较好的疗效性及安全性,值得在肝切除术中使用。
[Abstract]:Objective to compare the hemostatic effect of hemocoagulase of Agkistrodon acutus for injection and other hemostatic drugs in hepatectomy and to observe its clinical safety. Methods from November 2014 to February 2016, 122 patients undergoing hepatectomy by hepatobiliary surgery in our hospital were divided into two groups according to the criteria of preoperative inclusion and exclusion: group A of hemagglutinin for injection, group B of hemagglutinin for injection of Agkistrodon acutus) and acetic acid. In group C of desmotensin injection, according to the clinical study plan, the curative effect index (wound hemostasis time) of the three groups was determined. The wound bleeding volume 24 hours after operation and the safety indexes before and after operation (blood routine blood coagulation function liver and kidney function) were compared. Results there was no significant difference in wound hemostasis time, wound bleeding volume and drainage flow at 24 hours after operation among the three groups, and the blood routine examination, coagulation function, liver and kidney function indexes were compared between the groups before and after administration of the drug. There was no significant difference between the two groups (P 0.05). There was no abnormality in electrocardiogram (ECG) and B ultrasound examination of lower extremities at discharge. There were no adverse events in each group in this clinical study. Conclusion the hemostatic effect of hemocoagulase of Agkistrodon acutus for injection in hepatectomy is similar to that of other hemostatic drugs. It has no effect on blood routine, coagulation function, liver and kidney function, and has good curative effect and safety. It is worth using in hepatectomy.
【作者单位】：西南医科大学附属医院肝胆外科;
【分类号】：R657.3

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