脾切除贲周血管离断术对肝硬化患者术后血清MMP-1、TIMP-1及肝纤维化指标的影响

发布时间：2018-05-16 22:22

  本文选题：脾切除贲周血管离断术 + 肝硬化　； 参考：《临床外科杂志》2015年03期

【摘要】：目的探讨脾切除贲周血管离断术对慢性乙型肝炎肝硬化门静脉高压症患者肝纤维化指标及肝硬化病程的影响和可能机制。方法选择20例:HBsAg(+)、HBV-DNA(-)门静脉高压症患者,其中肝功能Child-Pugh A级14例,Child-Pugh B级6例。分别于脾切除贲周血管离断术前后,采用酶联免疫吸附试验(ELISA)法测定血清基质金属蛋白酶-1(MMP-1)和基质金属蛋白酶组织抑制因子-1(TMP-1);化学发光免疫法测定透明质酸(HA)、三型前胶原N端肽(PC-Ⅲ)、四型胶原(Ⅳ-C)、层粘连蛋白(LN)。结果 (1)血清TIMP-1及肝纤4项指标较术前明显下降(p0.05),MMP-1较术前缓慢升高(P0.05)。(2)TIMP-1与肝纤四项指标的变化成正相关关系(r=0.458~0.783,P0.01/0.05),MMP-1与肝纤4项指标的变化呈负相关关系(r=-0.545~-0.873,P0.01/0.05)。结论脾切除贲周血管离断术可使肝纤维化血清学指标和TIMP-1含量下降、MMP-1含量缓慢升高,有利于减缓肝硬化患者的病情进展。
[Abstract]:Objective to investigate the effect of splenectomy and pericardial devascularization on hepatic fibrosis and the course of liver cirrhosis in patients with chronic hepatitis B cirrhosis and portal hypertension. Methods Twenty cases of portal hypertension with HBV-DNA were selected, including 14 cases of Child-Pugh A grade of liver function and 6 cases of Child-Pugh B grade. Before and after splenectomy and pericardial devascularization, Serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of matrix metalloproteinase-1 (MMP-1) were determined by enzyme linked immunosorbent assay (Elisa), hyaluronic acid Ham, type 3 procollagen N-terminal peptide PC- 鈪，

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