颅内未破裂动脉瘤介入治疗程序相关性术中破裂的危险因素及临床特点分析

发布时间：2018-05-17 02:20

本文选题：颅内动脉瘤 + 介入治疗　；参考：《第二军医大学学报》2017年12期

【摘要】：目的探讨颅内未破裂动脉瘤介入治疗过程中发生术中破裂的危险因素及临床特点,为临床降低术中破裂的发生率提供对策。方法回顾性收集2010年1月至2017年2月间在第二军医大学长海医院接受介入治疗的1 232例颅内未破裂动脉瘤患者的临床资料,分析其临床及影像学特点,并对术中破裂可能的危险因素行单因素和多因素分析。结果 1 232例患者中有11例(0.89%)发生术中破裂。单因素分析结果显示心血管疾病史(P=0.025)、前交通动脉瘤(P=0.009)、肿瘤不规则形态(P=0.001)、支架应用(P=0.016)与术中破裂相关,多因素分析结果显示心血管疾病史(OR=6.919,P=0.008)、肿瘤不规则形态(OR=9.758,P0.001)、前交通动脉瘤(OR=4.648,P=0.024)为术中破裂的独立危险因素,支架应用为术中破裂的保护因素(OR=0.238,P=0.026)。结论心血管疾病史、不规则形态、前交通动脉瘤为颅内未破裂动脉瘤发生术中破裂的独立危险因素。支架治疗患者术中破裂的发生率低于非支架治疗患者。
[Abstract]:Objective to explore the risk factors and clinical features of intraoperative rupture of intracranial unruptured aneurysms during interventional therapy, and to provide countermeasures for reducing the incidence of intraoperative rupture. Methods the clinical data of 1 232 patients with unruptured intracranial aneurysms received interventional therapy from January 2010 to February 2017 in Changhai Hospital of second military Medical University were retrospectively collected and their clinical and imaging features were analyzed. The possible risk factors of intraoperative rupture were analyzed by univariate and multivariate analysis. Results intraoperative rupture occurred in 11 out of 1 232 patients. Univariate analysis showed that the history of cardiovascular disease (P0. 025), anterior communicating aneurysm (P0. 009), irregular shape of the tumor (P0. 001) and stent application (P0. 016) were associated with intraoperative rupture. The results of multivariate analysis showed that the risk factors of intraoperative rupture were 6.919 / P ~ (0.008), OR9.758 / P _ 0.001 and ORA 4.648 / P _ 0.024), and the protective factor of intraoperative rupture was 0.238P0.026A / P ~ (0.026) / 0.238P ~ (0.026) / P ~ (0.024), respectively. Conclusion the history of cardiovascular disease, irregular shape and anterior communicating aneurysm are independent risk factors for intraoperative rupture of intracranial unruptured aneurysms. The incidence of intraoperative rupture in stent patients was lower than that in non-stent patients.
【作者单位】：第二军医大学长海医院神经外科;
【基金】：国家重点研发计划(2016YFC1300700)~~
【分类号】：R651.12

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