药物灌注联合理疗治疗良性乳腺疾病乳头溢液的临床研究

发布时间：2018-05-22 10:12

本文选题：药物灌注 + 理疗　；参考：《青岛大学》2017年硕士论文

【摘要】：目的:分析乳头溢液的病因,探讨良性乳腺疾病乳头溢液的治疗方法,评价药物灌注联合理疗与单纯理疗对良性乳腺疾病乳头溢液的治疗效果,并分析两种不同的治疗方案对良性乳腺疾病乳头溢液预后的影响。方法:回顾性分析2014年1月至2015年12月就诊于寿光市妇幼保健院的乳头溢液患者的临床资料,根据研究入组标准,整理分析资料,选取良性乳腺疾病乳头溢液患者共164例,包括乳腺导管扩张伴炎症113例,单纯乳腺导管扩张51例。溢液性质表现为血性溢液、乳汁样溢液、水样溢液、浆液性溢液、脓性溢液。根据治疗方案分为2组,药物灌注联合理疗组86例,包括血性溢液1例,乳汁样溢液23例,水样溢液18例,浆液性溢液25例,脓性溢液19例。单侧乳房溢液55例,双侧乳房溢液31例。本组给予生理盐水、地塞米松、利多卡因联合甲硝唑药物灌注治疗联合理疗。单纯理疗组78例,包括血性溢液0例,乳汁样溢液22例,水样溢液19例,浆液性溢液21例,脓性溢液16例。单侧乳房溢液49例,双侧乳房溢液29例。本组给予单纯理疗。根据两种治疗方案的治疗效果,比较两种方案的差异,并对其进行评价。结果:所有患者均随访至2016年6月,随访时间6~12个月,药物灌注联合理疗组总体有效率为96.5%(83/86),单纯理疗组总体有效率为56.4%(44/78),两种方案对治疗良性乳腺疾病乳头溢液疾病均有效果,但药物灌注联合理疗组有效率明显高于单纯理疗组,两组有效率差异具有统计学意义(P0.05)。结论:良性乳腺疾病乳头溢液,可以给予保守治疗,给予药物灌注联合理疗的方法治疗,有显著的疗效,药物灌注联合理疗与单纯理疗相比较,治愈率明显提高,对通过药物灌注联合理疗得到治愈的患者,避免了手术,降低了该疾病的总体手术率,治疗过程安全有效,使患者生活质量得到明显提高。
[Abstract]:Objective: to analyze the etiology of nipple discharge, to explore the treatment method of nipple discharge of benign breast disease, and to evaluate the therapeutic effect of drug infusion combined with physiotherapy and physiotherapy alone on the treatment of benign breast disease nipple discharge. The effects of two different treatments on the prognosis of benign breast disease nipple discharge were analyzed. Methods: the clinical data of patients with nipple discharge from January 2014 to December 2015 in Shouguang Maternal and Child Health Hospital were retrospectively analyzed. According to the study criteria, 164 patients with nipple discharge of benign breast disease were selected. There were 113 cases of mammary duct dilatation with inflammation and 51 cases of simple mammary duct dilatation. The characteristics of the superfluous fluid are bloody, emulsion, water, serous and purulent. According to the treatment plan, 86 cases were divided into two groups, including 1 case of blood discharge, 23 cases of milk effusion, 18 cases of water overflow, 25 cases of serous discharge and 19 cases of purulent discharge. There were 55 cases of unilateral breast discharge and 31 cases of bilateral breast discharge. Normal saline, dexamethasone, lidocaine and metronidazole were given. There were 78 cases in physiotherapy group, including blood discharge (0 cases), lactation (22 cases), effusion (19 cases), serous discharge (21 cases) and purulent discharge (16 cases). There were 49 cases of unilateral breast discharge and 29 cases of bilateral breast discharge. This group was given simple physiotherapy. According to the therapeutic effects of the two treatments, the differences between the two schemes were compared and evaluated. Results: all the patients were followed up to June 2016, the follow-up time was 6 ~ 12 months, the total effective rate of the drug perfusion combined physiotherapy group was 96.5 / 86, and the total effective rate of the simple physiotherapy group was 56.4% 44 / 78. The two methods were effective in the treatment of benign breast disease nipple discharge disease. But the effective rate of drug perfusion combined physiotherapy group was significantly higher than that of simple physiotherapy group, the difference between the two groups was statistically significant (P 0.05). Conclusion: the nipple discharge of benign breast disease can be treated with conservative treatment and combined therapy of drug perfusion and physiotherapy. The cure rate of the combination of drug perfusion and physiotherapy is significantly higher than that of simple physiotherapy. For the patients cured by drug infusion combined with physiotherapy, the operation was avoided, the overall operation rate was reduced, the treatment process was safe and effective, and the quality of life of the patients was improved obviously.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R655.8

【参考文献】