绝经后骨质疏松症骨折危险因素及中医症状相关性研究

发布时间：2018-05-22 21:02

本文选题：绝经后骨质疏松症骨折 + 危险因素　；参考：《中国中西医结合杂志》2017年01期

【摘要】：目的探讨40~65岁女性发生绝经后骨质疏松症骨折的危险因素及中医症状的相关性。方法本研究采用登记式注册研究的方法,课题组于2009年3—8月在北京市东城区及上海市徐汇区收集的1 823例40~65岁女性骨质疏松症高危人群的危险因素及中医症状信息,进行连续3年的登记观察。同时采用Cox比例风险模型的方法,进行单因素、多因素分析,筛选与绝经后骨质疏松症骨折有关的危险因素及中医症状。结果截止到2011年12月共跟踪收集共有1 498条骨折信息,总应答率为82.17%,其中有52例发生了骨质疏松性骨折。以发生绝经后骨质疏松症骨折的时间为结局变量,Cox单因素分析中,平均年龄(RR=1.083,P=0.003)、是否绝经(RR=5.462,P=0.004)、平均绝经年限(RR=1.060,P=0.010)、绝经年限≤10年(RR=4.890,P=0.008)、绝经年限10年(RR=7.720,P=0.001)、生产次数≥3次(RR=5.870,P=0.003)、目眩(RR=3.037,P=0.001)、下肢拘挛(RR=2.315,P=0.003)及骨密度诊断为骨量减少(RR=2.376,P=0.008)、骨密度诊断为骨质疏松(RR=2.801,P=0.013)的回归参数β大于0,且RR值大于1,提示为绝经后骨质疏松症骨折的致病的危险因素。将骨密度测定诊断、年龄、绝经年限、生产次数、目眩、下肢拘挛6个因素进行Cox多因素分析,绝经年限10年(RR=3.257,P=0.032)及有目眩(RR=2.655,P=0.005)为其相关变量。结论 "目眩"及"绝经年限"是骨质疏松性骨折的最重要的危险因素,其中"目眩"可能早期预测骨质疏松性骨折的发生。
[Abstract]:Objective to investigate the risk factors of postmenopausal osteoporosis fracture and the correlation of TCM symptoms in women aged 40 to 65 years old. Methods in this study, the risk factors and TCM symptoms of 1 823 women aged 40 to 65 years old with osteoporosis were collected from March to August 2009 in Dongcheng District of Beijing and Xuhui District of Shanghai. To carry out three consecutive years of registration and observation. At the same time, the Cox proportional risk model was used to screen the risk factors and TCM symptoms related to the fracture of postmenopausal osteoporosis by univariate and multivariate analysis. Results by December 2011, a total of 1 498 fractures had been collected, and the total response rate was 82.17. Among them, 52 cases had osteoporosis fractures. The time of fracture of postmenopausal osteoporosis was used as the outcome variable in Cox single factor analysis. The mean age is RRH1.083 / P0.003, if the menopause is 5.462P0.004, the mean menopausal life is RR1.060P0.010, the menopause is less than 10 years, the menopausal age is RR7.720P0.001, the number of births is more than 3 times, the number of births is 5.870P0.003, the dizziness is RR3.037P0.001, the lower extremity RRnus is 2.315P0. 003) and the bone mineral density diagnosis is RRR2.376PfU 0.008, the diagnosis of bone density is osteoporosis. The regression parameter 尾 > 0 and RR value > 1 for RRN 2.801 Pu 0.013) suggests that it is a risk factor for postmenopausal osteoporosis fracture. Bone mineral density (BMD), age, years of menopause, number of births, dizziness, lower extremity clonus were analyzed by Cox multivariate analysis, with 10 years postmenopausal age of 3.257 (P = 0.032) and dizziness (RRN 2.655U, P 0.005) as the related variables. Conclusion dizziness and menopausal age are the most important risk factors for osteoporotic fracture, and dizziness may predict the occurrence of osteoporosis fracture early.
【作者单位】：中国中医科学院中医临床基础医学研究所;中国中医科学院望京医院科研处;中国人民大学统计学院;上海大华医院中医科;北京中医药大学附属东直门医院放射科;
【基金】：国家自然科学基金面上项目(No.81373885) 北京市中医院科技发展资金资助项目(No.JJ2015-57) 北京市中医药管理局青年基金资助项目(No.QN2016-02)
【分类号】：R580;R683

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