布比卡因用于蛛网膜下腔阻滞在高海拔与低海拔的比较

发布时间：2018-05-23 17:42

本文选题：布比卡因 + 麻醉　；参考：《中国新药与临床杂志》2017年10期

【摘要】：目的评价布比卡因用于蛛网膜下腔阻滞在高海拔与低海拔的麻醉效果。方法择期行下肢手术男性患者156例,ASAⅠ~Ⅱ级,均采用椎管内联合阻滞麻醉。高海拔组78例来自昌都市(海拔3 200 m),低海拔组78例来自重庆市(海拔250 m)。两组患者蛛网膜下腔均给予0.5%布比卡因注射液2 mL(10 mg)。记录两组的麻醉阻滞起效时间、麻醉阻滞最高平面、感觉阻滞持续时间及运动阻滞持续时间,观察围术期患者心率和血压变化。结果高海拔组麻醉阻滞起效时间(16±3)min,长于低海拔组[(10±2)min,P0.05],且高海拔组麻醉阻滞最高平面高于低海拔组(P0.05)。高海拔组的感觉阻滞持续时间和运动阻滞持续时间均短于低海拔组[(172±37)和(260±47)min vs.(223±39)和(336±50)min,P0.05]。围术期高海拔组患者心率均低于低海拔组,平均动脉压均高于低海拔组(P0.05)。结论 0.5%布比卡因10 mg蛛网膜下腔阻滞用于高海拔的患者有效,所需局麻药剂量高于低海拔地区。
[Abstract]:Objective to evaluate the effect of bupivacaine for subarachnoid block at high altitudes and low altitudes. Methods 156 male patients with lower extremity surgery, ASA I ~ II, were combined with intraspinal anesthesia. 78 cases from the high altitude group were from Changcheng (elevation 3200 m) and 78 from Chongqing (250 m). Two group of patients were from the low altitude group. The subarachnoid cavity was given 0.5% bupivacaine injection 2 mL (10 mg). Record the onset time of anesthesia block in two groups, the highest level of anesthesia, duration of sensory block and duration of motor block, and observe the changes of heart rate and blood pressure in the perioperative patients (16 + 3) min in high altitude group, longer than (10 + 2) MI in low altitude group. The highest level of anesthesia block in N, P0.05], and high altitude group was higher than that in low altitude group (P0.05). The duration of sensory block and duration of motor block were shorter in the high altitude group than in the low altitude Group [(172 + 37) and (260 + 47) min vs. (223 + 39) and (336 + 50) min. The heart rate of the patients in the high altitude group was lower than that in the low altitude group, and the average arterial pressure was higher. In low altitude group (P0.05). Conclusion 0.5% bupivacaine 10 mg subarachnoid block is effective in patients with high altitude, and the local anesthetic dose is higher than that in low altitude area.
【作者单位】：昌都市人民医院麻醉科;重庆市肿瘤研究所麻醉科;
【分类号】：R614

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