硫酸软骨素和壮骨关节丸联合治疗膝关节骨性关节炎关节痛的临床研究

发布时间：2018-05-25 17:35

本文选题：骨关节炎 + 关节痛　；参考：《青岛大学》2015年硕士论文

【摘要】：目的对硫酸软骨素和壮骨关节丸联合治疗骨性关节炎膝关节痛的临床疗效进行观察、评价,并探讨新的药物治疗方法,以替代非甾体抗炎药在骨性关节炎治疗中的作用。方法按照美国风湿病学会(ARA)采纳的《膝关节骨性关节炎诊断标准》及排除标准、膝关节骨性关节炎临床症状判定标准和Kellgren-Lawrence分级标准筛选出适合的实验对象,将筛选出并符合实验要求的实验对象随机分成治疗组与对照组,治疗组同时应用硫酸软骨素和壮骨关节丸治疗,对照组单纯应用双氯芬酸钠治疗,以膝关节骨性关节炎临床症状判定标准为判定治疗效果的主要依据,得出治疗前与治疗后评分之差。评价方法为差值15分者为优;11—15分者为良;6—10分为可;≤5分为差。结果应用SPSS17.0统计分析软件,对两组治疗效果的差异性进行非参数检验,检验水平α=0.05。所得相关数据为χ2=6.175,P=0.0460.05,可以认为两组间有显著差异,具有统计学意义。结论硫酸软骨素与壮骨关节丸的联合应用对骨性关节炎关节痛的治疗效果优于单纯应用双氯芬酸钠,有利于早、中期OA患者机体功能的改善。
[Abstract]:Objective To observe the clinical efficacy of chondroitin sulfate and Zhuanggu joint pill in the treatment of osteoarthritis of the knee joint pain, evaluate and explore new drug treatment methods to replace the role of non steroidal anti-inflammatory drugs in the treatment of osteoarthritis. Method according to the American rheumatology Society (ARA) "diagnostic criteria of osteoarthritis of the knee joint" The criteria of clinical symptoms determination and Kellgren-Lawrence grading standard for osteoarthritis of the knee were selected and the suitable subjects were selected. The selected subjects were randomly divided into the treatment group and the control group. The treatment group was treated with chondroitin sulfate and zhuangbone joint pills, and the control group was treated with dichloro alone. Sodium phenate was used as the main basis for judging the clinical symptoms of osteoarthritis of the knee joint. The difference between pre treatment and after treatment was the main basis for the treatment of osteoarthritis of the knee. The evaluation method was excellent in the difference value 15, 11 to 15, 6 to 10, and less than 5. The difference between the two groups was applied to the difference between the two groups. Non parameter test, the correlation data obtained by the level of level alpha =0.05. are Chi 2=6.175 and P=0.0460.05. It is considered that there are significant differences between the two groups. Conclusion the combined application of chondroitin sulfate and Zhuanggu joint pills is better than the simple application of diclofenac sodium in the treatment of osteoarthritis of joint pain. It is beneficial to early and medium term OA. The improvement of the function of the patient's body.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R684.3

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