五音吐纳疗法改善乳癌术后疲劳综合症的临床研究

发布时间：2018-05-28 09:38

本文选题：五音吐纳疗法 + 乳腺癌　；参考：《广州中医药大学》2015年硕士论文

【摘要】：目的：本研究通过量表评定的方法,对临床数据进行研究,记录并评价乳癌患者术后疲劳情况,观察五音吐纳疗法改善乳癌术后疲劳综合症的疗效,探索五音吐纳疗法的可行性,为乳癌术后疲劳综合症的中医治疗探索出一条行之有效的方法,拓宽五音吐纳疗法的临床应用范围,加深五音吐纳疗法和临床学科的相融性。方法：收集广东省第二中医院乳腺科2013年5月至2015年1月期间确诊为早期乳腺癌的患者共60例,采用区组随机化分组方法分为对照组和治疗组,对照组予术后常规治疗,治疗组予术后常规治疗配合五音吐纳疗法,采用视觉模拟评测表(Visual Analogue Scale, VAS)、简明心境量表(Brief Profile of Mood States,BPOMS)及围手术期疲劳测评量表(Identity-Consequence Fatigue Scale,ICFS)分别在术前、术后第1、3、7、14天同一时间点测评并记录分值,同时抽血检测术前、术后第7天白细胞(white blood cell,WBC)、红细胞(red blood cell, RBC)、血红蛋白(hemoglobin,HGB)、血小板(blood platelet,PLT)、血清总蛋白(serum total protein,STP)、血清白蛋白(serum albumin,ALB)及血清转铁蛋白(serum transferrin,TF)水平。采用SPSS17.0统计软件包,利用EXCEL建立数据库进行数据的管理和维护。统计方法有卡方检验、描述性统计分析方法、正态检验及方差齐性分析、两因素多水平重复测量方差分析、多变量方差分析方法、两样本秩和比较、两样本独立t检验等。结果：1.符合纳入标准的60例病例经VAS、BPOMS、ICFS量表评估,结果60例乳癌患者术后均出现不同程度的疲劳,其疲劳分值在不同的时间点存在差异。2.两组患者均在术后第1天的VAS、BPOMS、ICFS量表测评中得到较高的疲劳分值,术后第3天疲劳分值均较术前第1天下降,并且随着时间的推移疲劳分值较前降低。3.治疗组与对照组患者在术后第1天的VAS、BPOMS、ICFS量表的疲劳分值均处于较高水平,两组间差异没有统计学意义(P0.05)。治疗组患者术后第3、7、14天的VAS、BPOMS、CFS量表的疲劳分值比对照组患者低,差异有统计学意义(P0.05)。4.本研究中治疗组与对照组两组患者分别比较术前、术后第7天机体的WBC、RBC、HGB、PLT、STP及ALB水平,差异无统计学意义(P0.05)。五音吐纳疗法的干预不能改变机体WBC、RBC、HGB、PLT、STP及ALB的水平。结论：乳癌患者术后的确存在疲劳情况,其中术后第1天疲劳程度相对严重,且从术后第3天起呈逐渐改善的趋势。五音吐纳疗法对改善乳癌术后疲劳综合症的效果,主要体现在VAS、BPOMS、ICFS量表的疲劳分值的变化上,但不影响机体WBC、RBC、HGB、 PLT、STP及ALB水平的变化。五音吐纳疗法能有效地治疗乳癌术后疲劳综合症,具有可行性,值得进一步在临床实践中运用及推广。
[Abstract]:Objective: the purpose of this study was to study the clinical data, to record and evaluate the postoperative fatigue of patients with breast cancer, and to observe the curative effect of Wuyongna therapy on the improvement of postoperative fatigue syndrome of breast cancer. In order to explore the feasibility of five-tone toner therapy, explore an effective method for the treatment of postoperative fatigue syndrome of breast cancer, broaden the scope of clinical application of five-tone toner therapy, and deepen the compatibility of five-tone toner therapy and clinical subject. Methods: a total of 60 patients with early breast cancer from May 2013 to January 2015 were collected and randomly divided into two groups: control group and treatment group. The patients in the treatment group were treated with conventional postoperative therapy and five-tone toner therapy. Visual Analogue scale, VASA, brief Profile of Mood status scale (BPO MS) and Identity-Consequence Fatigue scale (ICFSs) were used before operation, respectively. The scores were measured and recorded at the same time point 14 days after operation, and the blood samples were taken before the operation. On the 7th day after operation, the levels of white blood cells, red blood cells, hemoglobin hGBs, platelet platelets, serum total protein, serum albumin (Alb) and serum transferrin (TF) were measured. Using SPSS17.0 statistical software package, using EXCEL to establish database for data management and maintenance. Statistical methods include chi-square test, descriptive statistical analysis method, normal test and homogeneity analysis of variance, two-factor multilevel repeated measurement variance analysis, multivariate variance analysis method, two-sample rank sum comparison, two-sample independent t-test, etc. The result is 1: 1. According to the inclusion criteria, 60 cases were evaluated by VAS-BPOMSMS-ICFS. Results all 60 cases of breast cancer had different degrees of fatigue after operation, and the fatigue scores were different at different time points. On the first day after operation, the fatigue scores of the two groups were higher than those on the first day after operation, and the fatigue scores on the third day after operation were lower than those on the first day before operation, and the fatigue scores decreased by .3with the passage of time. The fatigue scores of the VAS-BPOMSICFS scale in the treatment group and the control group were at a higher level on the first day after operation, and the difference between the two groups was not statistically significant (P 0.05). The fatigue score of VAS-BPOMS CFS scale in the treatment group was lower than that in the control group on the 3rd and 14th day after operation, and the difference was statistically significant (P 0.05). In this study, the STP and ALB levels of the patients in the treatment group and the control group were compared before and 7 days after operation respectively. There was no significant difference in STP and ALB levels between the two groups. The intervention of five tone and intonation therapy could not change the level of ALB and STP. Conclusion: postoperative fatigue does exist in patients with breast cancer, and the fatigue degree is relatively serious on the first day after operation, and gradually improves from the third day after operation. The effect of five-tone toning therapy on the improvement of postoperative fatigue syndrome of breast cancer was mainly reflected in the change of fatigue score of VAS-BPOMS ICFS scale, but it did not affect the changes of the levels of HGB, PLTN STP and ALB in patients with breast cancer. It is feasible to treat postoperative fatigue syndrome of breast cancer with five tones and it is worthy of further application and popularization in clinical practice.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.9

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