不同密度同种异体骨移植对犬脊柱融合术效果的影响

发布时间：2018-05-29 07:44

本文选题：脊柱融合术 + 椎体融合　；参考：《山东医药》2017年04期

【摘要】：目的探讨高密度与正常密度同种异体骨移植对犬脊柱融合术效果的影响。方法从32只中华田园犬中随机选取2只,处死后取其新鲜股骨,分别制备高密度和正常密度同种异体骨。将剩余每只中华田园犬的3个椎间隙(L1/2、L2/3、L3/4)进行标记,并随机分为对照组、高密度组和正常密度组,每组包括30个椎间隙。各组行脊柱融合术,正常密度组、高密度组摘除椎间盘后分别植入装有正常密度、高密度同种异体骨的融合器,对照组仅行椎间盘摘除,不植入同种异体骨。观察动物术后进食、活动及切口愈合等一般情况。术后12周处死实验动物,取出融合术后节段脊柱(L1~4),分别经医师手法检查和影像学检查判断椎体融合情况,计算融合率。结果实验动物术后精神可,饮食良好,活动自由,无瘫痪,切口愈合良好,无感染,体质量无明显变化。手法检查结果显示,对照组椎体融合率为0(0/30),高密度组为27.58%(8/29),正常密度组为71.43%(20/28);影像学检查结果显示,对照组椎体融合率为0(0/30),高密度组为41.38%(12/29),正常密度组为71.43%(20/28);高密度组和正常密度组椎体融合率均高于对照组,正常密度组椎体融合率高于高密度组(P均0.05)。结论与高密度同种异体骨移植比较,犬脊柱融合术中采用正常密度同种异体骨移植后的椎体融合率高。
[Abstract]:Objective to investigate the effect of high density and normal density allograft bone graft on spinal fusion in dogs. Methods two of 32 Chinese idyllic dogs were randomly selected and their fresh femurs were sacrificed to prepare high density and normal density allogeneic bone respectively. The 3 intervertebral spaces of each Chinese pastoral dog were labeled L 1 / 2 L 2 / 3 L 3 / 4) and were randomly divided into control group, high density group and normal density group. Each group included 30 intervertebral spaces. Each group was treated with spinal fusion, normal density group and high density group were implanted with normal density and high density allograft bone fusion cage respectively, while the control group was only treated with intervertebral disc excision, and no allograft bone was implanted. Observe the general situation of feeding, movement and wound healing after operation. The experimental animals were killed 12 weeks after operation and the fusion rate was calculated by means of manipulative examination and imaging examination. Results the experimental animals had good mental health, good diet, free movement, no paralysis, good wound healing, no infection and no obvious changes in body mass. The results of manual examination showed that the fusion rate of vertebral body in the control group was 0 / 30, in the high density group was 27.58 / 29, and in the normal density group was 71.43 / 20 / 28. The fusion rate of the control group and the normal density group was 0 / 30, 41.3812 / 29 and 71.43 / 28 / 28 respectively, and the fusion rate of the high density group and the normal density group was higher than that of the control group, and the fusion rate of the normal density group was higher than that of the high density group (P 0.05). Conclusion compared with high density bone allograft, the spinal fusion rate of canine spinal fusion with normal density bone allograft is higher.
【作者单位】：遵义医学院附属医院;
【基金】：贵州省卫生厅科学技术基金资助项目(gzwkj2013-1-011)
【分类号】：R687.3

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