臭氧与透明质酸治疗膝骨性关节炎安全性和有效性的Meta分析

发布时间：2018-05-29 22:23

本文选题：骨关节炎 + 膝　；参考：《重庆医学》2017年09期

【摘要】：目的运用Meta分析的方法,比较臭氧(O3)与透明质酸(HA)治疗膝骨性关节炎(KOA)的安全性和有效性。方法系统检索PubMed、Cochrane Library(2016年第1期)、Embase、CNKI、CBM、VIP、Wan-Fang数据库中相关临床随机对照试验(RCT),检索时限为各数据库建库至2016年1月23日。两名研究者独立筛选文献、提取数据,并行研究方法学质量评价。运用RevMan5.3和Stata13.0进行统计分析。结果纳入20个RCT,合计2 136例KOA患者。与HA治疗KOA比较,O3治疗有效率较高[比值比(OR)=2.78,P0.01];缓解疼痛效果更佳[治疗后1、3、6个月:均数差(MD)=-0.25、-0.71、-1.70,均P0.01]。二者并发症比较差异无统计学意义(OR=0.84,P=0.56)。结论当前证据显示O3对KOA近期疗效优于HA,安全性二者相当。
[Abstract]:Objective to compare the safety and efficacy of ozone O3 (O3) and hyaluronic acid (HA) in the treatment of knee osteoarthritis (OA) by Meta. Methods A systematic search was carried out for RCTT in the relevant clinical randomized controlled trials (RCTT) in the database of PubMedus Cochrane Library (issue 1, 2016). The time limit for retrieval was to be established until January 23, 2016, and the relevant clinical randomized controlled trials (RCTT) were conducted in the database of CBMN VIPN Wan-Fang in 2016. The two researchers independently sifted the literature, extracted data and studied the quality evaluation of methodology in parallel. RevMan5.3 and Stata13.0 were used for statistical analysis. Results Twenty RCTs were included in 2 136 patients with KOA. Compared with HA treatment, the effective rate of KOA was higher than that of HA [the ratio was 2.78% P0.01], and the pain relief was better than that of HA [after 1, 6 months, the mean value was 0.25- 0.71 ~ (-1) ~ (-1) (P0.01)]. There was no significant difference in complications between the two groups. Conclusion the present evidence shows that O 3 is superior to HAA in the treatment of KOA in the short term, and the safety of O 3 is the same.
【作者单位】：十堰市太和医院/湖北医药学院附属医院显微骨科;湖北医药学院附属襄阳医院骨科;湖北医药学院附属襄阳医院循证医学中心;
【分类号】：R684.3

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