纳米氧化锌在骨科中的应用前景

发布时间：2018-06-04 00:20

  本文选题：纳米氧化锌 + 骨科　； 参考：《中国矫形外科杂志》2017年18期

【摘要】：置入物术后感染和骨折术后骨不连一直是骨科手术失败的主要原因。为了降低感染的风险,促进骨缺损区成骨活动,置入材料表面镀纳米氧化锌膜的研究比较多。目前体外和动物试验已证实纳米氧化锌抗菌性能和成骨活性优异,同时具有较好的生物相容性。纳米氧化锌在钛合金、多孔钽、羟基磷灰石晶须、骨肿瘤、骨水泥、抗菌敷料等骨科材料的应用充分展示了其优良的抗菌活性和成骨活性。但是纳米氧化锌临床研究较少,真正应用于骨科还需要更进一步的研究。未来还需要进一步明确纳米氧化锌在人体内的安全浓度以及有效浓度,保证其抗菌的安全性和有效性。本文对纳米氧化锌的作用机理、在骨科中的应用及其生物相容性进行综述。
[Abstract]:Infection after implantation and nonunion after fracture have been the main causes of failure of orthopedic surgery. In order to reduce the risk of infection and promote osteogenesis in the bone defect area, there are many studies on the implantation of nano-ZnO film on the surface of the material. At present, nano-zinc oxide has been proved to have excellent antibacterial and osteogenic activity in vitro and animal experiments, as well as good biocompatibility. The application of nano-zinc oxide in titanium alloy, porous tantalum, hydroxyapatite whisker, bone tumor, bone cement, antibacterial dressing and other orthopedic materials showed its excellent antibacterial activity and osteogenic activity. However, there are few clinical studies on nano zinc oxide, and further research is needed for its application in orthopaedics. In the future, the safety and effective concentration of nanometer zinc oxide in human body should be further determined to ensure the safety and effectiveness of its antibacterial activity. In this paper, the mechanism, application and biocompatibility of nanometer zinc oxide in orthopedics were reviewed.
【作者单位】： 南昌大学第二附属医院骨科江西骨科研究所;高安市人民医院骨二科;
【基金】：江西省卫生厅科技项目(编号:20141059)
【分类号】：R68
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本文编号：1974915