右美托咪定复合地佐辛用于肝癌切除术后PCIA对机体细胞免疫功能的影响

发布时间：2018-06-04 19:56

本文选题：右美托咪定 + 地佐辛　；参考：《东南大学学报(医学版)》2017年01期

【摘要】：目的:探讨右美托咪定复合地佐辛用于肝癌切除术后病人自控静脉镇痛(PCIA)对机体细胞免疫功能的影响。方法:将120例拟行肝癌切除术患者采用随机数字表法分为两组,复合组给予地佐辛1.0 mg·kg~(-1)+右美托咪定1.0μg·kg~(-1),对照组给予地佐辛1.0mg·kg~(-1)。分别于麻醉诱导前(T0)、气管导管拔除即刻(T1)以及术后12 h(T2)、24 h(T3)、48 h(T4)、72 h(T5)对患者进行疼痛VAS评分,测定外周血中CD3~+、CD4~+、CD8~+淋巴细胞亚群及NK细胞水平。结果:术后12~72 h复合组各个时点VAS均明显低于对照组(均P0.001)。与T0相比,复合组T1、T2时点CD3~+、CD4~+、CD4~+/CD8~+及NK细胞水平均明显下降(均P0.05),T3时点CD3~+和NK细胞水平明显下降(均P0.05)。组间比较:T2时点复合组CD3~+、CD4~+及NK细胞水平均明显高于对照组(P0.05),T3时点复合组CD3~+和NK细胞水平明显高于对照组(P0.05),T4时点复合组CD3~+水平明显高于对照组(P0.05)。结论:右美托咪定复合地佐辛用于肝癌切除术PCIA效果更好,可以改善患者细胞免疫功能。
[Abstract]:Aim: to investigate the effect of dexmetomidine combined with dizosin on cellular immune function of patient controlled intravenous analgesia (PCIA) after hepatectomy. Methods: 120 patients undergoing hepatectomy were randomly divided into two groups: the compound group was given dizosin 1.0 mg / kg, and the control group was given dizosin 1.0mg (1.0 渭 g / kg). The VAS scores of pain were assessed before anesthesia induction, tracheal catheter extubation (T1) and 12 h after operation. The levels of CD3 ~ + CD4 ~ + CD8 ~ + lymphocyte subsets and NK cells in peripheral blood were measured. Results: the VAS of the compound group was significantly lower than that of the control group at 1272 hours postoperatively (P 0.001). Compared with T0, the levels of CD3 ~ + CD4 ~ + CD4 ~ / CD8 ~ and NK cells in T _ 1 / T _ 2 group were significantly lower than those in T _ 0 group (P < 0.05) and NK cell levels were significantly decreased (P < 0.05). The levels of CD3 ~ and NK cells in the control group were significantly higher than those in the control group at the time point of P0.05 / T _ 3 and the levels of CD3 ~ and NK cells in the control group were significantly higher than those in the control group at the time point P0.05T _ 4 and the level of NK cells was significantly higher than that in the control group. Conclusion: dexmetomidine combined with dizosin is more effective in hepatectomy with PCIA, and can improve the cellular immune function of patients.
【作者单位】：广州市第八人民医院麻醉科;
【分类号】：R614;R735.7

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