丁丙诺啡透皮贴剂在人工膝关节置换术后的镇痛效果

发布时间：2018-06-04 22:06

本文选题：丁丙诺啡透皮贴剂 + 术后镇痛　；参考：《广东医学》2017年S1期

【摘要】：目的观察丁丙诺啡透皮贴剂用于人工膝关节置换术后疼痛的抑制效果。方法选取行择期单侧人工全膝关节置换术的患者56例,采用随机单盲法分成两组,每组28例,其中对照组患者于术后常规口服氨酚曲马多,观察组患者于术前1 d应用丁丙诺啡透皮贴剂,术后常规口服氨酚曲马多。记录术后6、12 h、1~7 d的膝关节静息时的视觉模拟评分(VAS)评分;术后1周内每天主动活动时的VAS评分;术后1周内每天被动活动时的VAS评分;术后1周内每天膝关节主动伸屈活动度数;追加镇痛药物量;不良反应记录;患者总体满意度。结果观察组患者术后2~7 d时静息状态下VAS评分、术后2~7 d每天主动活动状态下VAS评分、术后2~6 d每天CPM被动活动状态下VAS评分与对照组比较均有明显减少,差异均有统计学意义(P0.05)。术后追加镇痛药两组差异无统计学意义(P0.05)。两组均无明显不良反应发生。患者总体满意度观察组优于对照组。结论丁丙诺啡透皮贴剂用于人工膝关节置换术后镇痛效果良好,有利于术后关节功能的改善。
[Abstract]:Objective to observe the effect of buprenorphine transdermal patch on pain after knee arthroplasty. Methods Fifty-six patients undergoing elective total knee arthroplasty were randomly divided into two groups: 28 patients in each group. The control group received routine oral administration of aminophenol tramadol after operation. The patients in the observation group were treated with buprenorphine transdermal patch 1 day before operation. Visual analogue score (VAS) of knee joint at rest was recorded at 6 h / 12 h / 7 d, VAS score at active activity 1 week after operation, VAS score at passive activity 1 week after operation, visual analogue score (VAS) at rest of knee joint at 1 day after operation, and visual analogue score (VAS) at rest 7 days after operation. The degree of active extension and flexion of knee joint every day 1 week after operation; additional analgesic drug dosage; adverse reaction record; patients' overall satisfaction. Results the VAS score of the patients in the observation group was significantly lower than that in the control group at the 7th day after operation, the VAS score in the active state on the 7th day after operation, and the VAS score in the passive state of CPM on the 2nd day after operation, and in the passive state of CPM on the 6th day after operation, as compared with that in the control group. The difference was statistically significant (P 0.05). There was no significant difference between the two groups in the addition of analgesics after operation (P 0.05). No significant adverse reactions occurred in both groups. The overall satisfaction of patients in observation group was better than that in control group. Conclusion buprenorphine transdermal patch has a good analgesic effect after knee arthroplasty and is beneficial to the improvement of postoperative joint function.
【作者单位】：珠海市人民医院创伤骨科;南方医科大学第三附属医院关节外科;
【分类号】：R687.4

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