重型颅脑损伤监测降钙素原和超敏C反应蛋白对感染的鉴别诊断应用

发布时间：2018-06-05 07:14

本文选题：重型颅脑损伤 + 肺部感染　；参考：《基因组学与应用生物学》2016年11期

【摘要】：探讨重型颅脑损伤监测降钙素原和超敏C反应蛋白对感染的鉴别诊断应用。选择我院2015年1月至2016年1月所接诊的80例重型颅脑损伤患者,其中40例伴有肺部感染作为感染组,其余40例为未感染组,在感染当天检测降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平,感染组患者给予相应的抗感染治疗后,根据患者感染情况进行分组,在感染后3 d、感染后7 d时分别对PCT、hs-CRP水平进行检测。在感染当天,感染组PCT、hs-CRP水平均比未感染组高((3.85±0.51)ng/m L比(0.53±0.15)ng/m L,(61.23±17.34)mg/L比(50.12±13.12)mg/L)(p0.05);在感染组患者中,24例患者感染好转,感染后3 d、感染后7 d时,PCT、hs-CRP水平均比确认感染当天得到降低(p0.05);另外16例患者感染持续,在感染后3 d、感染后7 d时,PCT、hs-CRP水平均发生持续性升高,与确认感染当天比较差异具有统计学意义(p0.05)。PCT和hs-CRP的检测在重型颅脑损伤并发肺部感染患者中具有较高的特异性敏感性,有利于临床评估。
[Abstract]:To investigate the application of monitoring procalcitonin and hypersensitive C reactive protein in the differential diagnosis of severe craniocerebral injury. From January 2015 to January 2016, 80 patients with severe craniocerebral injury were selected, including 40 patients with pulmonary infection and 40 patients with no infection. The levels of procalcitonin protopril (PCT) and hypersensitive C-reactive protein (hs-CRP) were measured on the day of infection. The patients in the infection group were divided into groups according to the infection status after the corresponding anti-infection treatment. The levels of PCThs-CRP were detected at 3 days after infection and 7 days after infection. On the day of infection, the levels of hs-CRP in the infected group were higher than those in the non-infected group (3.85 卤0.51)ng/m L vs 0.53 卤0.15)ng/m L, 61.23 卤17.34)mg/L vs 50.12 卤13.12 mg / L, respectively). The levels of PCThs-CRP at 3 days after infection and 7 days after infection were lower than those on the day of confirmed infection, and the levels of PCThs-CRP in 16 other patients continued to increase at 3 days after infection and 7 days after infection. Compared with the confirmed infection day, the detection of p0.05, PCT and hs-CRP in patients with severe craniocerebral injury complicated with pulmonary infection has a high specificity and sensitivity, which is helpful for clinical evaluation.
【作者单位】：西南医科大学附属医院神经外科;内江市第一人民医院神经外科;
【分类号】：R651.15

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