骨科术后感染患者的IL-6与IL-8及T淋巴细胞亚群变化研究

发布时间：2018-06-06 15:46

  本文选题：骨科术后 + 感染　； 参考：《中华医院感染学杂志》2017年20期

【摘要】：目的探讨骨科患者在手术后发生感染情况及检测白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和T淋巴细胞亚群水平变化的临床研究,为骨科术后感染的临床防治和治疗提供参考依据。方法选取2014年12月-2016年10月期间医院进行骨科手术的患者65例为研究对象,对患者的术后感染发生情况进行统计,术后发生感染患者21例作为感染组,术后未发生感染患者44例设为对照组,并将感染患者的致病菌进行培养鉴定,同时观察患者的IL-6、IL-8及T淋巴细胞亚群的变化。结果研究中的65例骨科术后患者有21例发生感染,感染率为32.31%;感染患者共计检测病原菌84株,其中革兰阴性菌51株占60.71%,革兰阳性菌29株占34.52%,真菌4株占4.76%;感染患者的IL-6(42.16±3.52)ng/L、IL-8(54.15±7.91)ng/L明显高于非感染患者的IL-6(14.81±7.35)ng/L、IL-8(42.18±10.17)ng/L水平;感染患者的CD_3~+(58.29±6.04)%、CD_4~+(43.94±2.75)%、CD_4~+/CD_8~+(0.64±0.03)明显高于非感染患者的CD_3~+(49.01±5.72)%、CD_4~+(22.59±3.27)%、CD_4~+/CD_8~+(1.08±0.31)。结论骨科患者在术后发生感染的情况较为严重,其中革兰阴性菌感染居多,感染患者的IL-6、IL-8与T淋巴细胞亚群水平较非感染患者明显升高,提示可作为临床判断术后感染的重要指标。
[Abstract]:Objective to investigate the incidence of infection in orthopedic patients after surgery and to investigate the changes of interleukin-6 (IL-6), interleukin-8 (IL-8) and T lymphocyte subsets in orthopedic patients, and to provide a reference for the prevention and treatment of postoperative infection in orthopedic patients. Methods Sixty-five patients undergoing orthopedic surgery in hospital from December 2014 to October 2016 were selected as subjects. The incidence of postoperative infection was statistically analyzed. 21 patients with postoperative infection were selected as infection group. Forty-four patients without infection after operation were set up as control group. The pathogenic bacteria of infected patients were cultured and identified. The changes of IL-6 IL-8 and T-lymphocyte subsets were observed at the same time. Results among the 65 orthopedic patients in the study, 21 cases were infected, the infection rate was 32.31%, 84 strains of pathogenic bacteria were detected in the infected patients. 鍏朵腑闈╁叞闃存，

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