青海成人大骨节病患者血清NO、TNF-α、IL-1β和HA含量分析

发布时间：2018-06-09 05:36

  本文选题：大骨节病 + 一氧化氮　； 参考：《中国地方病防治杂志》2017年02期

【摘要】：目的检测青海成人大骨节病患者血清一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和透明质酸(HA)含量,探讨NO、TNF-α、IL-1β和HA在青海大骨节病发生发展的机理。方法选择青海省贵德和兴海县大骨节病区与西宁市非大骨节病区272例调查对象,分为大骨节病组(91)、病区对照组(92)、非病区对照组(89),平均年龄、性别无差别。采集静脉血制备血清,用酶联免疫吸附实验(ELISA)检测血清NO、TNF-α、IL-1β和HA含量。结果(1)3组间血清NO含量大骨节病组病区内对照组病区外对照组(P0.05);(2)3组间血清TNF-α含量,大骨节病组和病区内对照组病区外对照组(P0.05),但大骨节病组和病区内对照组无显著性差异(P0.05);(3)3组间血清IL-1β含量,大骨节病组和病区内对照组病区外对照组(P0.05),但大骨节病组和病区内对照组无显著性差异(P0.05);(4)3组间血清HA含量,大骨节病组和病区内对照组病区外对照组(P0.05),但大骨节病组和病区内对照组无显著性差异(P0.05)。结论青海成人大骨节病的发生发展与NO、TNF-α、IL-1β水平的升高和HA水平的降低有关。
[Abstract]:Objective to detect the levels of serum nitric oxide (no), tumor necrosis factor- 伪 (TNF- 伪), interleukin-1 尾 (IL-1 尾) and hyaluronic acid (HA) in patients with Kashin-Beck disease (KBD) in Qinghai province, and to explore the mechanism of the occurrence and development of KBD in Qinghai Province. Methods 272 cases of Kaschin-Beck disease (KBD) area in Guide and Xinghai County of Qinghai Province and non-KBD area in Xining City were divided into two groups: KBD group (n = 91), control group (n = 92) and control group (n = 89). There was no difference in average age and sex. Venous blood was collected to prepare serum and serum NONT-NF- 伪 IL-1 尾 and HA were detected by enzyme linked immunosorbent assay (Elisa). Results the level of serum no in KBD group was higher than that in control group (P 0.05) and TNF- 伪 content in serum between KBD group and KBD group. The levels of serum IL-1 尾 in KBD group and control group were not significantly different from those in KBD group and control group, but there was no significant difference in serum IL-1 尾 content between KBD group and KBD group, but there was no significant difference in serum IL-1 尾 content between KBD group and control group. However, there was no significant difference in serum HA content between KBD group and control group (P 0.05), but there was no significant difference in serum HA content between KBD group and control group (P 0.05), but there was no significant difference in serum HA content between KBD group and control group (P 0.05), but there was no significant difference in serum HA content between KBD group and control group. There was no significant difference in KBD group and control group, but there was no significant difference between KBD group and control group. Conclusion the occurrence and development of Kaschin-Beck disease in Qinghai is related to the increase of TNF- 伪 IL-1 尾 and the decrease of HA level.
【作者单位】： 青海省地方病预防控制所;
【基金】：青海省科技计划项目(2014-ZJ-754)
【分类号】：R684.1
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本文编号：1999189