帕金森病患者面临的骨折风险的Meta分析

发布时间：2018-06-12 21:11

本文选题：骨质疏松 + 骨折　；参考：《重庆医学》2017年33期

【摘要】：目的评估帕金森病患者是否有更高骨折发生率。方法检索中国生物医学数据库、中国知网、万方数据库、维普数据库、Cochrane Library、Web of Science、MEDLINE和EMBASE,同时辅以手工检索,时间截止到2017年2月。搜集关于帕金森病患者骨折发生率的队列研究,对纳入研究进行数据提取和治疗评价后加以分析。结果共检索出1 160篇文献,最终11篇队列研究被纳入,共计988 723例受试者。分析显示帕金森组患者发生骨折的风险明显高于对照组(RR=2.09,95%CI:1.91~2.28),其中髋部骨折发生率明显高于对照组(RR=2.33,95%CI:1.79~3.02),脊柱骨折发生率差异无统计学意义(RR=1.33,95%CI:0.78~2.27),帕金森组男性与女性患者发生髋部骨折的风险均明显高于对照组(RR=2.40、1.69,95%CI:2.21~2.60、1.62~1.76)。结论帕金森病患者发生骨折的风险明显高于健康人,由于纳入研究存在一定地区偏倚和发表性偏倚风险,今后还需要更多高质量的临床研究来准确评估帕金森病患者骨折风险是否更高。
[Abstract]:Objective to evaluate whether Parkinson's disease has a higher fracture rate. Methods Chinese Biomedical Database, China knowledge Network, Wanfang Database, Weip Database, Cochrane Library Web of Science and Technology MEDLINE and EMBASE were retrieved by hand until February 2017. Cohort studies on the incidence of fractures in Parkinson's disease were collected and analyzed after data extraction and treatment evaluation. Results A total of 1,160 articles were retrieved, and 11 cohort studies were included in the study, a total of 988,723 subjects. The analysis showed that the risk of fracture in the Parkinson group was significantly higher than that in the control group. The incidence of hip fracture was significantly higher than that in the control group. The incidence of hip fracture was significantly higher than that in the control group. There was no significant difference in the incidence of spinal fracture. There was no significant difference in the incidence of spinal fracture between male and female patients in Parkinson's group. The risk of raw hip fracture was significantly higher than that of the control group. Conclusion the risk of fracture in patients with Parkinson's disease is significantly higher than that in healthy persons. More high-quality clinical studies are needed to accurately assess whether Parkinson's patients have a higher fracture risk.
【作者单位】：重庆市人民医院创伤骨科;
【基金】：重庆市卫生和计划生育委员会科研基金资助项目(2016MSXM064)
【分类号】：R683;R742.5

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