中脑腹侧被盖区多巴胺神经元在全身麻醉中的作用研究

发布时间：2018-06-16 09:16

本文选题：丙泊酚麻醉 + 异氟醚麻醉　；参考：《重庆医学》2017年17期

【摘要】：目的探讨中脑腹侧被盖区(VTA)多巴胺神经元在全身麻醉诱导和苏醒中的作用。方法成年健康雄性SD大鼠40只,分为毁损组(n=20)和对照组(n=20),毁损组在双侧VTA给予特异性多巴胺神经元毁损药6-羟多巴胺(6-OHDA)减少多巴胺神经元,对照组在双侧中脑腹侧被盖区给予等量生理盐水。待手术后两周,观察在全身麻醉下,大鼠翻正反射消失时间(LORR)和恢复时间(RORR)。结果与对照组相比,在丙泊酚麻醉下可显著缩短大鼠LORR(P0.05),且明显延长大鼠RORR(P0.05)。在异氟醚麻醉下毁损组与对照组相比,大鼠LORR,差异无统计学意义(P0.05),但大鼠RORR延长(P0.05)。结论 VTA多巴胺神经元在不同的全身麻醉药的诱导和苏醒发挥着有不同作用。
[Abstract]:Objective to investigate the role of VTA-dopaminergic neurons in the induction and recovery of general anesthesia in ventral tegmental area. Methods Forty adult male Sprague-Dawley rats were divided into two groups: the damage group (n = 20) and the control group (n = 20). The lesion group was treated with 6-hydroxydopamine 6-OHDA-reducing dopamine neuron in bilateral VTA. The control group was given the same amount of normal saline in bilateral ventral tegmental area. After two weeks of operation, we observed the time of disappearance of righting reflex (LORR) and recovery time (RORRV) under general anesthesia in rats. Results compared with the control group, propofol anesthesia could significantly shorten the LORRN P0.05A and prolong the RORRN P0.05U significantly. Compared with the control group, there was no significant difference of LORRin rats under isoflurane anesthesia, but the RORR was prolonged in rats. Conclusion VTA dopamine neurons play different roles in induction and recovery of different general anesthetics.
【作者单位】：遵义医学院麻醉系;
【基金】：国家自然科学基金资助项目(81560237)
【分类号】：R614.2

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