回顾性分析活血、抗凝药物在门脉高压脾切除术后的作用

发布时间：2018-06-17 19:42

本文选题：门脉高压症 + 脾切除术　；参考：《山西医科大学》2015年硕士论文

【摘要】：目的:回顾性分析活血、抗凝药物在门脉高压症脾切除术后预防门静脉血栓形成的作用方法:回顾性收集山西医科大学第一临床医学院及山西省人民医院2009年9月—2014年9月收治的门静脉高压症,并行脾切除术加贲门周围血管离断术,根据术后是否应用活血、抗凝药物分为实验组27例(早期应用活血、抗凝药物),对照组33例(未应用活血、抗凝药物),观察两组在术后2个月内凝血变化、肝功能的变化及门静脉系统的血栓形成情况,比较两组的性别、年龄、手术前和手术后各自的肝功能变化情况以及手术后发生门静脉血栓的情况,同时采用统计学手段进行分析。结果:对照组和实验组在一般情况(包括性别、年龄、脾脏大小、门静脉及脾静脉周径)、发病原因、肝功能分级以及手术前后各项生化指标无明显差异(P0.05)。术后,对照组形成门静脉血栓的发生率为33.3%,实验组形成门静脉血栓的发生率为7.4%,两者之间的差异具有显著的统计学意义(P0.05)。结论:术后早期应用活血、抗凝药物可降低门脉高压脾切除术后门静脉血栓的发生,实验组未发生出血等情况,也未出现与使用活血、抗凝药物有关的并发症。
[Abstract]:Objective: to retrospectively analyze blood circulation, Effects of anticoagulants on prevention of portal vein thrombosis after splenectomy in patients with portal hypertension methods: the first Clinical College of Shanxi Medical University and the people's Hospital of Shanxi Province from September 2009 to September 2014 were collected retrospectively. Combined with splenectomy and pericardial devascularization, 27 cases of experimental group were divided into two groups according to whether or not to use blood circulation and anticoagulant drugs (early application of activating blood circulation, anticoagulant therapy) and control group of 33 cases (no application of activating blood circulation). Anticoagulant drugs were used to observe the changes of coagulation, liver function and thrombosis of portal vein system in the two groups within 2 months after operation, and to compare the sex and age of the two groups. The changes of liver function before and after operation and portal vein thrombosis after operation were analyzed statistically. Results: there were no significant differences between the control group and the experimental group (including sex, age, spleen size, portal vein and splenic vein diameter, the cause of the disease, liver function grading and biochemical indexes before and after operation). After operation, the incidence of portal vein thrombosis in the control group was 33.3%, and that in the experimental group was 7.4%. The difference between the two groups was statistically significant (P 0.05). Conclusion: the early application of blood circulation and anticoagulant drugs can reduce the occurrence of venous thrombosis in the back door of portal hypertension splenectomy, and there is no bleeding in the experimental group, and there are no complications related to the use of blood circulation and anticoagulant drugs.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R657.6

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