氨甲环酸对老年陈旧性股骨颈骨折伴骨质疏松行髋关节置换术失血的影响

发布时间：2018-06-19 14:39

本文选题：氨甲环酸 + 髋　；参考：《中国老年学杂志》2017年01期

【摘要】：目的探讨氨甲环酸对减少老年陈旧性股骨颈骨折伴骨质疏松患者行髋关节置换术失血的有效性及安全性。方法 56例老年陈旧性股骨颈骨折伴骨质疏松拟行单侧人工全髋关节置换术的患者随机分为两组,各28例。手术切开皮肤前10 min开始按15 mg/kg氨甲环酸加入100 ml生理盐水中静脉滴注,对照组则输入100 ml生理盐水。比较两组患者围术期总失血量、术中出血量、隐性失血量、术后引流血量、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)。结果两组患者围术期总失血量、隐性失血量、术中出血量、术后引流血量有统计学差异(P0.05),两组术后PT、APTT差异均无显著性(P0.05)。结论静脉使用氨甲环酸能显著性减少老年陈旧性股骨颈骨折伴骨质疏松患者行全髋关节置换术的围术期总失血量、术中失血量及隐性失血量,且不增加下肢深静脉血栓形成的风险。
[Abstract]:Objective to investigate the efficacy and safety of methionine in reducing blood loss in elderly patients with old femoral neck fracture associated with osteoporosis. Methods 56 cases of old femoral neck fracture with osteoporosis were randomly divided into two groups. 10 min before the incision of the skin, the rats were injected intravenously with 15 mg/kg carbamoic acid in 100ml normal saline, while the control group was given 100ml saline. The total blood loss, intraoperative blood loss, recessive blood loss, postoperative drainage volume, prothrombin time (PTT) and activated partial thrombin time (APTTT) were compared between the two groups. Results there were significant differences in total blood loss, recessive blood loss, intraoperative blood loss and postoperative drainage volume between the two groups (P 0.05), but there was no significant difference in PTT APTT between the two groups (P 0.05). Conclusion intravenous use of carbamoic acid can significantly reduce the perioperative total blood loss, intraoperative blood loss and recessive blood loss in elderly patients with old femoral neck fracture associated with osteoporosis. And does not increase the risk of deep venous thrombosis in the lower extremity.
【作者单位】：成都医学院第一附属医院关节外科;
【基金】：四川省科技厅项目(No.2014SZ0035)
【分类号】：R687.4;R580

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