腰大池引流加鞘内注射治疗对高血压脑出血术后颅内感染患者血清NSE与hs-CRP和PCT的影响

发布时间：2018-06-22 14:58

本文选题：腰大池引流 + 万古霉素　；参考：《中华医院感染学杂志》2017年12期

【摘要】：目的研究腰大池引流加鞘内注射治疗高血压脑出血术后颅内感染患者的临床效果,并探讨其对患者血清神经元特异性烯醇化酶(NSE)、超敏C-反应蛋白(hs-CRP)及降钙素原(PCT)的影响。方法选取2013年1月-2016年1月于医院行手术治疗后发生颅内感染80例高血压脑出血患者为研究对象,根据治疗方案分成对照组与研究组,各40例,对照组单独给予腰大池引流治疗,观察组在对照组基础上实施万古霉素鞘内注射治疗,比较两组患者临床治疗效果。结果研究组患者治疗后1个月GOS评分明显优于对照组,差异有统计学意义(P0.05);两组患者治疗后7d血清NSE、hs-CRP及PCT水平均降低,且上述各项指标研究组改善程度明显优于对照组,差异均有统计学意义(P0.05);研究组治疗总有效率为95.00%,明显高于对照组治疗总有效率75.00%,差异有统计学意义(P0.05)。结论腰大池引流加鞘内注射治疗高血压脑出血术后颅内感染患者效果显著,有效降低血清NSE、hs-CRP、PCT水平,改善患者临床症状。
[Abstract]:Objective to study the clinical effect of lumbar cistern drainage combined with intrathecal injection in the treatment of intracranial infection after hypertensive intracerebral hemorrhage (hypertensive intracerebral hemorrhage), and to investigate the effect of the treatment on serum neuron specific enolase (NSE), hypersensitive C-reactive protein (hs-CRP) and procalcitonin (PCT). Methods from January 2013 to January 2016, 80 patients with hypertensive intracerebral hemorrhage (hypertensive intracerebral hemorrhage) were divided into control group and study group, 40 cases in each group. The control group was treated with lumbar cistern drainage alone, the observation group was treated with vancomycin intrathecal injection on the basis of the control group, and the clinical effects of the two groups were compared. Results the GOS score in the study group was significantly better than that in the control group at one month after treatment (P0.05), the serum NSEhs-CRP and PCT levels in the two groups were decreased 7 days after treatment, and the improvement degree of the above indexes in the study group was significantly better than that in the control group. The difference was statistically significant (P0.05); the total effective rate of treatment in the study group was 95.00 significantly higher than that in the control group 75.000.The difference was statistically significant (P0.05). Conclusion Lumbar cistern drainage combined with intrathecal injection in the treatment of intracranial infection after hypertensive intracerebral hemorrhage is effective in reducing the serum NSEhs-CRP PCT level and improving the clinical symptoms of the patients.
【作者单位】：温州医科大学附属第三医院神经外科;温州市中心医院神经外科;
【基金】：浙江省卫生适宜技术成果转化计划基金资助项目(B类)(2014RCA026)
【分类号】：R651.1

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