11β-羟基类固醇脱氢酶在骨代谢调控中的评价

发布时间：2018-06-25 07:28

本文选题：代谢 + 骨和骨组织　；参考：《中国组织工程研究》2017年32期

【摘要】：背景:糖皮质激素既是成骨细胞分化所必需,但过量又会抑制成熟成骨细胞的表型,11β-羟基类固醇脱氢酶可以调控糖皮质激素的活性,使糖皮质激素的利用结果最优化。目的:综述11β-羟基类固醇脱氢酶在骨代谢过程中发挥的作用。方法:由通讯作者检索至2016年的Pub Med数据库、相关期刊论文的相关文章,英文关键词为"11β-HSD,Bone",中文检索词为"11β-羟基类固醇脱氢酶,骨"。找到英文文献98篇,中文文献17篇,检索文献量总计115篇。共保留45篇做进一步分析。结果与结论:(1)11β-羟基类固醇脱氢酶对糖皮质激素的活性有重要的受体前水平调节作用;(2)11β-羟基类固醇脱氢酶的活性可以预测个体骨代谢受糖皮质激素影响的敏感度,可以根据个体差异性精准使用糖皮质激素的用量;(3)11β-羟基类固醇脱氢酶的活性与成骨细胞的分化活跃度密切相关,分化活跃的成骨细胞可以抑制自身11β-羟基类固醇脱氢酶的活;(4)糖皮质激素促进小鼠颅骨发育,并不是直接影响间叶细胞,而是通过影响成熟成骨细胞再间接作用于间叶细胞;(5)短期应用糖皮质激素可以直接促进11β-羟基类固醇脱氢酶的表达,而长期应用糖皮质激素可以间接抑制11β-羟基类固醇脱氢酶的表达。
[Abstract]:Background: glucocorticoid is necessary for osteoblast differentiation, but excessive glucocorticoid can inhibit the phenotype of mature osteoblasts and regulate the activity of glucocorticoid and optimize the utilization of glucocorticoid. Objective: to review the role of 11 尾-hydroxysteroid dehydrogenase in bone metabolism. Methods: the relevant articles of Pub Med database and full text database of Chinese periodicals were searched by the author in 2016. The key words were "11 尾 -HSDbone" in English and "11 尾 -hydroxysteroid dehydrogenase, bone" in Chinese. 98 English literatures, 17 Chinese literatures and 115 retrieval papers were found. A total of 45 articles were retained for further analysis. Results and conclusion: (1) 11 尾 -hydroxysteroid dehydrogenase has important prereceptor regulation on glucocorticoid activity, and (2) 11 尾 -hydroxysteroid dehydrogenase activity can predict the sensitivity of bone metabolism to glucocorticoid. The dosage of glucocorticoid can be accurately used according to individual differences. (3) the activity of 11 尾 -hydroxysteroid dehydrogenase is closely related to the activity of osteoblast differentiation. Differentiation and active osteoblasts can inhibit the activity of 11 尾 -hydroxysteroid dehydrogenase. (4) glucocorticoid promotes the development of mouse skull, but does not directly affect mesenchymal cells. (5) short-term application of glucocorticoid could directly promote the expression of 11 尾 -hydroxysteroid dehydrogenase. Long-term glucocorticoids could indirectly inhibit the expression of 11 尾-hydroxysteroid dehydrogenase.
【作者单位】：北京大学中日友好临床医学院;北京中日友好医院骨关节外科;
【基金】：北京市自然科学基金(7174346) 国家自然科学基金面上项目(81372013,81672336) 中日友好医院院级课题(2014-4-QN-29);中日友好医院青年科技英才计划(2014-QNYC-A-06)~~
【分类号】：R68

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