右美托咪定联合芬太尼对骨科手术患者术后镇痛效果及血流动力学的影响

发布时间：2018-06-27 15:29

本文选题：右美托咪定 + 芬太尼　；参考：《中国药房》2017年24期

【摘要】：目的:探讨右美托咪定联合芬太尼对骨科手术患者术后镇痛效果及血流动力学的影响。方法:80例拟行骨科手术患者随机分为观察组(40例)和对照组(40例)。观察组患者给予盐酸右美托咪定注射液+枸橼酸芬太尼注射液自控镇痛(PCA),镇痛维持48 h。对照组患者给予枸橼酸芬太尼注射液PCA,镇痛维持48 h。观察两组患者从应用多功能监护仪到连接PCA时(T_0)、连接后12 h(T_1)、48 h(T_2)的平均动脉压(MAP)、血氧饱和度(SpO_2)、心率(HR)、疼痛视觉模拟(VAS)评分及不良反应发生情况。结果:T_0时,两组患者VAS评分比较,差异均无统计学意义(P0.05)。T_(1-2)时,两组患者VAS评分均显著高于同组T_0时,T_1显著高于T_2,但观察组显著低于对照组同期,差异均有统计学意义(P0.05)。两组患者不同时间点的MAP、SpO_2、HR比较,差异均无统计学意义(P0.05)。观察组患者呼吸抑制、剧痛、恶心呕吐、低血压发生率均显著低于对照组,差异均有统计学意义(P0.05)。结论:右美托咪定联合芬太尼用于骨科手术患者术后的镇痛效果显著,对血流动力学无影响,且安全性较好。
[Abstract]:Objective: to investigate the effect of dexmetomidine combined with fentanyl on postoperative analgesia and hemodynamics in orthopedic patients. Methods 80 patients undergoing orthopedic surgery were randomly divided into observation group (n = 40) and control group (n = 40). Patients in the observation group were given patient-controlled analgesia (PCA) with dexmetomidine hydrochloride injection fentanyl citrate injection for 48 hours. The patients in the control group were treated with fentanyl citrate injection for 48 h. The mean arterial pressure (map), blood oxygen saturation (SPO _ 2), heart rate (HR), visual analogue of pain (VAS) and adverse reactions were observed in the two groups from multifunctional monitor to PCA (TCI _ 0), 12 h (T _ 1) and 48 h (T _ 2) after connection. Results there was no significant difference in VAS scores between the two groups (P0.05). T1-2, the VAS scores of the two groups were significantly higher than those of the same group, but the VAS scores in the observation group were significantly lower than those in the control group (P0.05). There was no significant difference between the two groups at different time points (P0.05). The incidence of respiratory depression, severe pain, nausea and vomiting, hypotension in the observation group was significantly lower than that in the control group (P0.05). Conclusion: dexmetomidine combined with fentanyl is effective in postoperative analgesia for orthopedic patients, has no effect on hemodynamics, and is safe.
【作者单位】：无锡市第三人民医院麻醉科;
【分类号】：R614

【相似文献】