右美托咪定对肺癌术后患者微循环的影响

发布时间：2018-06-28 00:00

本文选题：右美托咪定 + 肺癌　；参考：《中国现代医学杂志》2017年23期

【摘要】：目的观察2种剂量右美托咪定(Dex)对肺癌根治术后机械通气患者微循环的影响。方法选取肺癌术后入重症监护室行机械通气的患者60例,按随机数字表法分为A、B两组,每组30例,分别静脉微泵0.6和0.8μg/(kg·h)剂量的Dex。观察并记录给药前(T_0)和给药后15 min(T_1)、30 min(T_2)、1 h(T_3)、2 h(T_4)的心率(HR)、收缩压(SBP)、舒张压(DBP)、心输出量(CO)、经皮氧分压(Tc PO_2)、经皮二氧化碳分压(Tc PCO_2)、氧分压(Pa O_2)、二氧化碳分压(Pa CO_2)及血乳酸(Lac)值。记录心血管不良事件的发生情况。结果两组不同时间血流动力学指标有差异,均呈下降趋势,以B组更明显,两组组间各指标比较,差异无统计学意义(P0.05);两组不同时间Pa O_2、Pa CO_2及Tc PCO_2比较,差异无统计学意义(P0.05);两组不同时间Lac比较,差异有统计学意义(P0.05),呈上升趋势。两组不同时间Tc PO_2比较,差异有统计学意义(P0.05),两组给药后变化趋势比较,差异有统计学意义(P0.05),两组Tc PO_2均较用药前升高。结论 0.6μg/(kg·h)Dex泵注肺癌术后机械通气患者,血流动力学更稳定,微循环改善更显著。
[Abstract]:Objective to observe the effect of two doses of dexmetomidine (Dex) on microcirculation in patients with mechanical ventilation after radical resection of lung cancer. Methods Sixty patients with lung cancer received mechanical ventilation in intensive care unit after operation were randomly divided into two groups: group A (n = 30) and group A (n = 30) with intravenous micropump of 0.6 渭 g / (kg h) and 0.8 渭 g / (kg h) respectively. The heart rate (HR), systolic blood pressure (SBP), diastolic pressure (DBP), cardiac output (CO), percutaneous partial oxygen pressure (Tc PCO2), partial pressure of oxygen (O 2), partial pressure of carbon dioxide (CO 2), partial pressure of CO 2 (CO 2), partial pressure of oxygen (CO 2), partial pressure of CO 2 (CO 2) and values of blood lactate (Lac) were observed and recorded before and 15 min after administration. Record the occurrence of adverse cardiovascular events. Results the hemodynamic indexes of the two groups were different at different time and showed a downward trend, especially in group B, and there was no significant difference between the two groups (P 0.05), and there was no significant difference between the two groups (P0.05), and there was no significant difference between the two groups at different time points (P < 0.05). The difference was not statistically significant (P0.05); the two groups of different time Lac comparison, the difference was statistically significant (P0.05), showing an upward trend. TcPO2 in the two groups at different time, the difference was statistically significant (P0.05), the change trend of the two groups after administration, the difference was statistically significant (P0.05), the two groups Tc-PO2 were higher than before treatment. Conclusion 0.6 渭 g / (kg h) Dex pump has more stable hemodynamics and improved microcirculation in patients with lung cancer after mechanical ventilation.
【作者单位】：徐州医科大学江苏省麻醉学重点实验室;徐州医科大学附属医院重症医学科;
【分类号】：R614;R734.2

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