早期大剂量乌司他丁联合沐舒坦治疗特重度烧伤对患者呼吸功能及炎性因子的影响

发布时间：2018-06-28 04:51

本文选题：乌司他丁 + 沐舒坦　；参考：《中华全科医学》2016年01期

【摘要】：目的探讨早期大剂量乌司他丁联合沐舒坦治疗特重度烧伤对患者呼吸功能及炎性因子水平的影响。方法收集特重度烧伤患者100例,随机分为观察组与对照组各50例,2组患者均给予常规烧伤方案治疗,同期观察组患者给予早期乌司他丁40万U联合450 mg大剂量沐舒坦治疗,对照组给予早期乌司他丁10万U联合沐舒坦30 mg常规剂量治疗,观察2组患者治疗后呼吸功能指标及炎性因子水平变化情况。结果 12组患者治疗后呼吸频率、PaO2、PaO2/Fi O2各时间点单因素重复测量方差分析有统计学意义(P0.05);观察组治疗7、12 d后呼吸频率较对照组下降明显,治疗3、7、12 d后PaO2、PaO2/Fi O2较对照组升高明显,2组比较差异有统计学意义(P0.05);22组患者治疗后血清TNF-α、IL-1、IL-6、IL-8水平各时间点单因素重复测量方差分析有统计学意义(P0.05),治疗3、7 d血清TNF-α、IL-1、IL-6、IL-8水平增高,治疗12 d各指标水平下降;观察组治疗3、7 d血清TNF-α、IL-1、IL-6、IL-8水平增高低于对照组,12 d下降较对照组显著,2组比较差异均有统计学意义(P0.05)。结论早期大剂量乌司他丁联合沐舒坦治疗特重度烧伤对保护呼吸功能、调低炎症因子水平临床效果显著。
[Abstract]:Objective to investigate the effects of early high dose ulinastatin combined with ambroxol on respiratory function and inflammatory factors in patients with severe burn. Methods A total of 100 patients with severe burn were randomly divided into two groups: the observation group (n = 50) and the control group (n = 50) were treated with routine burn regimen. The patients in the observation group were treated with early ulinastatin 400000 U combined with 450mg ambroxol at the same time. The control group was treated with ulinastatin 100000 U and ambroxol 30 mg. The changes of respiratory function and inflammatory factors were observed after treatment. Results there was statistical significance in ANOVA of repeated measurement of respiratory frequency and PaO2 / Pao _ 2 / fi _ 2 at each time point after treatment in 12 groups (P0.05), and the respiratory frequency in observation group was significantly lower than that in control group after 7 days of treatment. There was significant difference in serum TNF- 伪 -IL-1IL-6IL-8 level after treatment for 12 days after treatment (P0.05), and the serum TNF- 伪 IL-1IL-6IL-6IL-8 level was increased at 37 days after treatment (P0.05), and the level of TNF- 伪 IL-1IL-6IL-6IL-8 was increased at 37 days after treatment (P0.05), and the level of TNF- 伪 -IL-1IL-6 / IL-8 was significantly higher than that of control group (P0.05), and the level of IL-6IL-8 was significantly higher than that of control group (P0.05). The levels of serum TNF- 伪 IL-1IL-6 + IL-8 in the observation group were significantly lower than those in the control group on the 12th day after treatment (P0.05), and the levels of serum TNF- 伪 -IL-1-, IL-6- + IL-8 in the observation group were significantly lower than those in the control group on the 12th day after treatment (P0.05). Conclusion early high dose ulinastatin combined with ambroxol can protect respiratory function and lower the level of inflammatory cytokines.
【作者单位】：解放军第118医院烧伤科;温州医科大学附属第一医院烧伤科;
【基金】：南京军区医学科研课题(MS035)
【分类号】：R644

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