银屑病关节炎病情活动与血清TNF-α、IL-6水平和实验室指标相关性分析

发布时间：2018-06-29 02:21

本文选题：银屑病关节炎 + TNF-α　；参考：《中国地方病防治杂志》2017年03期

【摘要】：目的探讨银屑病关节炎(psoriatic arthritis,Ps A)患者病情活动情况与血清肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)水平和实验室指标的相关性。方法选取Ps A患者65例,观察全部患者临床资料、实验室指标,进行银屑病关节炎临床分型和疾病严重程度的分级(classification critetia for psoriatic arthritis,CASPAR2006)指数评估,采用ELISA法检测血清TNF-α、IL-6水平,分析病情及实验室指标的相关性。另选取同期20例正常人作为对照组,进行对比分析。结果 Ps A患者血清TNF-α、IL-6水平明显增高,并与血沉(ESR)、C反应蛋白(CRP)呈正相关,与血清白蛋白水平呈负相关。结论 Ps A患者血清中TNF-α、IL-6水平明显增高,并反映其病情的活动性,具有临床指导意义。
[Abstract]:Objective to investigate the correlation between the state of disease and serum levels of tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6) and laboratory indexes in patients with psoriatic arthritis (psoriatic arthritis PS A). Methods 65 patients with PS A were selected and the clinical data and laboratory indexes were observed. The clinical classification and severity of psoriatic arthritis (classification critetia for psoriatic arthritis CASPAR2006) index were evaluated. The serum TNF- 伪 IL-6 levels were detected by Elisa. The correlation between disease condition and laboratory indexes was analyzed. In addition, 20 normal persons were selected as control group in the same period for comparative analysis. Results the serum levels of TNF- 伪 and IL-6 were significantly increased in patients with PS A, and were positively correlated with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), and negatively correlated with serum albumin levels. Conclusion the serum levels of TNF- 伪 and IL-6 in patients with PS A are significantly higher and reflect the activity of the disease, which is of clinical significance.
【作者单位】：西安市第五医院;西安交通大学地方病研究所;
【基金】：陕西省卫生厅科研项目(2012D25) 西安市卫计委科研计划项目(J201603041)
【分类号】：R684.3;R758.63

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