局部应用氨甲环酸联合肾上腺素对减少全髋关节置换术失血量的影响

发布时间：2018-06-29 20:00

本文选题：肾上腺素 + 氨甲环酸　；参考：《实用医学杂志》2017年02期

【摘要】：目的:探讨局部应用氨甲环酸(TXA)联合肾上腺素在减少全髋关节置换术(THA)后失血量的有效性和安全性。方法:将90例准备行THA的患者随机分为2组:TXA联合肾上腺素组(联合组,n=45)以及对照组(TXA组,n=45)。联合组向关节腔内注射TXA和肾上腺素,TXA组向关节腔内注射TXA。比较两组患者术中失血量、术后引流量、总失血量、隐性失血量、血红蛋白(Hb)下降值以及红细胞比容(Hct)下降值,同时比较分析两组患者输血率以及并发症的发生率。结果:TXA联合肾上腺素可以明显减少THA患者术后引流量、总失血量以及隐形失血量、输血率、Hb下降值以及Hct下降值,差异均有统计学意义(P0.05),对于术中出血量,两组之间差异并无统计学意义(P0.05)。两组患者术后并发症的发生率比较差异无统计学意义(P0.05)。结论:TXA联合肾上腺素对减少单侧THA术后出血的疗效明确且不会增加患者术后并发症的发生。
[Abstract]:Objective: to investigate the efficacy and safety of local application of TXA combined with epinephrine in reducing blood loss after total hip arthroplasty (tha). Methods: 90 patients with tha were randomly divided into 2 groups: TXA + epinephrine group (TXA + epinephrine group) and control group (TXA group). TXA was injected into the articular cavity in the combined group and TXA was injected into the articular cavity in the adrenoceptor TXA group. The blood loss, postoperative drainage, total blood loss, recessive blood loss, hemoglobin (HB) and erythrocyte volume (HCT) were compared between the two groups. The rate of blood transfusion and the incidence of complications in the two groups were compared and analyzed. Results the volume of blood loss, total blood loss and invisible blood loss, blood transfusion rate, HB and HCT decreased significantly in patients with tha after operation (P0.05). There was no significant difference between the two groups (P0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P0.05). Conclusion the effect of TXA combined with epinephrine on reducing bleeding after unilateral tha is clear and does not increase the incidence of postoperative complications.
【作者单位】：河北医科大学附属唐山工人医院骨外二科;河北医科大学附属唐山工人医院胸外科;
【分类号】：R687.4

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