丁苯酞对老年高血压性脑出血钻孔引流术治疗后神经功能及预后的影响

发布时间：2018-07-01 16:21

本文选题：丁苯酞氯化钠注射液 + 钻孔引流术　；参考：《中国药房》2017年26期

【摘要】：目的:探讨丁苯酞氯化钠注射液对老年高血压性脑出血(HICH)钻孔引流术治疗后神经功能及预后的影响。方法:选取2015年1月-2016年6月我院收治的老年HICH患者80例作为研究对象,按照随机数字表法分为对照组和观察组,各40例。两组患者均接受钻孔引流术治疗,对照组患者术后给予常规治疗;观察组患者于术后第5天在对照组基础上给予丁苯酞氯化钠注射液100 mL,ivgtt,bid。两组患者均治疗14 d。观察两组患者临床疗效和两组存活患者术前及术后28 d中国脑卒中临床神经功能缺损程度评分量表(CSS)评分,比较两组患者术前及术后14 d脑水肿体积、血清同型半胱氨酸(HCY)和P物质(SP)水平。结果:两组患者各病死1例,观察组患者临床总有效率为87.5%,显著高于对照组的67.5%,差异有统计学意义(P0.05)。术前,两组存活患者CSS评分、脑水肿体积、血清HCY、SP水平比较,差异均无统计学意义(P0.05);术后28 d,两组存活患者CSS评分显著降低,术后14 d,两组患者SP水平显著升高,血清HCY水平显著降低,脑水肿体积显著缩小,且观察组患者上述指标显著优于对照组,差异均有统计学意义(P0.05)。结论:丁苯酞氯化钠注射液能显著提高老年HICH患者钻孔引流术后的临床疗效,改善神经功能缺损,减轻术后脑水肿,并且能够降低血清HCY水平,提高SP水平。
[Abstract]:Objective: to investigate the effect of butyphthalide sodium chloride injection on nerve function and prognosis in elderly patients with hypertensive intracerebral hemorrhage (HICH). Methods: 80 elderly HICH patients treated in our hospital from January 2015 to June 2016 were selected and divided into control group (n = 40) and observation group (n = 40). The patients in the two groups were treated with drilling and drainage, the patients in the control group were treated with routine treatment after operation, and the patients in the observation group were treated with 100 mL sodium phthalide chloride injection on the basis of the control group on the 5th day after operation. Both groups were treated for 14 days. To observe the clinical efficacy of the two groups and the scores of neurological deficit scale (CSS) before and 28 days after operation in the two groups, and to compare the volume of brain edema between the two groups before and 14 days after operation. Serum homocysteine (HCY) and substance P (SP) levels. Results: one patient died in each of the two groups. The total effective rate of the observation group was 87.5, which was significantly higher than that of the control group (P 0.05). Before operation, there was no significant difference in CSS score, cerebral edema volume and serum HCYN SP level between the two groups (P0.05), but at 28 days after operation, the CSS score of survival patients in both groups decreased significantly, and at 14 days after operation, the SP level of the two groups increased significantly. The level of serum HCY was significantly decreased and the volume of brain edema was significantly reduced. The above indexes in the observation group were significantly better than those in the control group (P0.05). Conclusion: butyphthalide sodium chloride injection can significantly improve the clinical effect after drilling and drainage in elderly patients with HICH, improve neurological function defect, reduce postoperative cerebral edema, and reduce serum HCY level and SP level.
【作者单位】：汉中3201医院神经外科;延安大学医学院生物化学与分子生物学教研室;延安市人民医院神经外科;
【分类号】：R651.12

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