骨碎补总黄酮联合全身振动对绝经后骨质疏松性椎体压缩性骨折术后的影响

发布时间：2018-07-02 12:03

本文选题：骨碎补总黄酮 + 全身振动　；参考：《中国骨质疏松杂志》2017年09期

【摘要】：目的评价骨碎补总黄酮联合全身振动(whole-body vibration,WBV)对绝经后骨质疏松性椎体压缩性骨折PVP术后的影响。方法 129例的绝经后骨质疏松性椎体压缩性骨折纳入本研究,随机分为骨碎补总黄酮组、全身振动组及联合治疗组,所有患者均接受经皮椎体成形术(PVP)治疗;骨碎补总黄酮组术后给予骨碎补总黄酮治疗,全身振动组术后给予全身振动治疗;联合治疗组术后给予骨碎补总黄酮联合全身振动治疗,治疗为期6个月。对3组患者治疗前后的疼痛VAS评分、腰椎及髋部骨密度、血清总碱性磷酸酶(alkaline phosphatase,ALP)、血清Ⅰ型胶原羧基端肽交联(carboxy-telopeptide of type I collagen,β-CTX)及血钙(Ca)、磷(P)变化情况进行对比,同时对患者服药后的不良反应发生率进行比较。结果治疗6个月后3组患者VAS评分均较治疗前有明显改善(P0.05),且联合治疗组患者评分明显低于骨碎补总黄酮组及全身振动组(P0.05)。治疗6个月后,3组患者骨密度较治疗前显著改善(P0.05),血清Ca、P、ALP和β-CTX较治疗前有显著改变(P0.05),且联合治疗组均明显优于骨碎补总黄酮组及全身振动组(P0.05)。3组药品不良反应发生率比较,差异无统计学意义(P0.05)。结论骨碎补总黄酮联合全身振动降低绝经后骨质疏松椎体压缩性骨折PVP术后VAS评分,且能改善髋部腰椎骨密度,安全性较高,值得在临床中推广应用。
[Abstract]:Objective to evaluate the effect of whole-body VibrationWBV on postmenopausal osteoporotic vertebral compression fracture. Methods 129 cases of postmenopausal osteoporotic vertebral compression fracture were randomly divided into three groups: total flavonoids group, whole body vibration group and combined treatment group. All the patients were treated with percutaneous vertebroplasty (PVP). The total flavone group was treated with total flavone after operation, the whole body vibration group was treated with whole body vibration after operation, and the combined treatment group was treated with total flavone and whole body vibration for 6 months. VAS scores, bone mineral density of lumbar spine and hip, serum alkaline phosphatase, carboxy-telopeptide of type I collagenase (尾 -CTX), serum calcium (Ca) and phosphorus (P) were compared before and after treatment. At the same time, the incidence of adverse reactions after taking medicine was compared. Results after 6 months of treatment, the VAS scores in the three groups were significantly improved compared with those before treatment (P0.05), and the scores in the combined treatment group were significantly lower than those in the total flavonoids group and the whole body vibration group (P0.05). After 6 months of treatment, the bone mineral density (BMD) of the three groups was significantly improved than that of the control group (P0.05), and the serum levels of Catropicin ALP and 尾 -CTX were significantly changed (P0.05), and the incidence of adverse drug reactions in the combined treatment group was significantly better than that in the total flavonoid group and the whole body vibration group (P0.05), and the incidence of adverse drug reactions in the combined treatment group was significantly higher than that in the whole body vibration group (P0.05). The difference was not statistically significant (P0.05). Conclusion Total flavonoids combined with whole body vibration can reduce the VAS score of postmenopausal osteoporotic vertebral compression fracture after PVP and can improve the bone mineral density of hip lumbar vertebrae. It is safe and worthy to be popularized in clinic.
【作者单位】：青海省海西州人民医院骨科;
【分类号】：R580;R687.3

【相似文献】