软组织肉瘤远隔软组织转移25例临床病理特点及预后分析

发布时间：2018-07-07 17:43

本文选题：软组织肉瘤 + 软组织转移　；参考：《中国肿瘤临床》2017年01期

【摘要】：目的:分析软组织肉瘤(soft tissue sarcoma,STS)远隔软组织转移患者的临床特点、预后影响因素及不同治疗手段的疗效差异,为其临床诊疗提供参考。方法:收集2010年6月至2016年6月北京大学肿瘤医院骨与软组织肿瘤科收治的发生远隔软组织转移的STS患者25例。统计分析其临床病理特点及预后情况。结果:25例远隔软组织转移患者中同时性转移6例(24%),异时性转移者19例(76%),原发灶手术后到出现转移病灶的平均时间为45.3个月。转移灶最常见的部位是躯干,共18例(72%)患者,其次为头颈部5例(20%)。本组患者1年总生存率80%,3年总生存率33%,11例(44%)伴有肺转移患者3年总生存率较差,差异具有统计学意义。结论:STS远隔软组织转移患者中组织学分级2级、无肺转移者有更高的总生存率;新辅助化疗、手术为主的综合治疗是主要治疗方案,靶向治疗作为新的治疗手段呈现较好的疗效。
[Abstract]:Objective: to analyze the clinical features, prognostic factors and therapeutic effects of distant soft tissue metastasis of soft tissue sarcoma (soft tissue sarcoma), and to provide reference for clinical diagnosis and treatment. Methods: from June 2010 to June 2016, 25 STS patients with distant soft tissue metastasis were collected from the Department of Bone and soft tissue Oncology, Peking University Oncology Hospital. Its clinicopathological features and prognosis were analyzed statistically. Results among 25 cases of distant soft tissue metastasis, 6 cases (24%) had simultaneous metastasis and 19 cases (76%) had heterochronous metastasis. The average time from primary operation to metastatic lesion was 45.3 months. The most common site of metastasis was trunk, 18 cases (72%), followed by 5 cases (20%) of head and neck. The 1-year overall survival rate was 80%, the 3-year overall survival rate was 33% (44%) and the 3-year overall survival rate was poor in patients with pulmonary metastasis. Conclusion the histologic grade 2 of the patients with distant soft tissue metastasis of the patients without lung metastasis has a higher overall survival rate, the neoadjuvant chemotherapy and the combined treatment of surgery are the main treatment schemes. As a new treatment method, targeted therapy has a better effect.
【作者单位】：北京大学肿瘤医院暨北京市肿瘤防治研究所骨与软组织肿瘤科恶性肿瘤发病机制及转化研究教育部重点实验室;
【分类号】：R738

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