富血小板血浆修复膝关节骨关节炎

发布时间：2018-07-08 10:10

本文选题：组织工程 + 膝　；参考：《中国组织工程研究》2016年42期

【摘要】：背景:富血小板血浆因含有大量血小板源性生长因子对膝骨性关节炎有较好的疗效,但目前对关节面软骨的修复效果尚有争议。目的:观察富血小板血浆对兔膝骨关节炎模型的关节软骨修复作用。方法:采用Hulth法建立右膝骨关节炎兔模型,分别于右膝关节腔灌注富血小板血浆和玻璃酸钠,并设置模型组和假手术组作对比。造模后8周,测定各组兔关节滑液中一氧化氮水平,观察关节面形态及软骨修复情况。结果与结论:(1)关节面软骨形态比较:富血小板血浆治疗组关节面损伤修复情况明显好于其他3组;(2)富血小板血浆治疗组软骨组织Mankin’s评分和关节液中一氧化氮水平均低于模型组和玻璃酸钠治疗组(P0.05),高于假手术组(P0.05);(3)结果说明:膝关节腔灌注富血小板血浆对兔膝骨关节炎模型的关节软骨修复效果较好,效果优于玻璃酸钠灌注。
[Abstract]:Background: platelet-rich plasma containing a large number of platelet-derived growth factors has a good effect on knee osteoarthritis, but the repair effect of articular cartilage is still controversial. Objective: to observe the effect of platelet-rich plasma on articular cartilage repair in rabbit knee osteoarthritis model. Methods: the rabbit model of right knee osteoarthritis was established by Hulth method. Platelet-rich plasma and sodium hyaluronate were perfused into the right knee joint cavity respectively. After 8 weeks, the levels of nitric oxide in synovial fluid of rabbits were measured, and the morphology of articular surface and cartilage repair were observed. Results and conclusion: (1) the morphology of articular surface cartilage: the repair of articular surface injury in the platelet-rich plasma treatment group was better than that in the other three groups, (2) the Mankinsscale of cartilage tissue and the nitric oxide in articular fluid in the platelet-rich plasma treatment group were significantly better than those in the other three groups. The levels were lower than those in the model group and sodium hyaluronate treatment group (P0.05), and higher than those in the sham-operated group (P0.05); (3). The results showed that platelet-rich plasma perfusion into the knee joint cavity had a better effect on the repair of articular cartilage in rabbit knee osteoarthritis model. The effect was better than sodium hyaluronate infusion.
【作者单位】：成都体育学院;
【基金】：四川省科技厅项目(2014SZ0003-3)~~
【分类号】：R684.3

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